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Table 1 Distributions and optimal ranges of pre-miRNA quantifiable features. We calculated the distributions of quantifiable features, namely GC content, core mfe, hairpin mfe and the ratio of core mfe to hairpin mfe. Because of the existence of extreme values, we adopted the reference value rather than the original distribution ranges in the Sequence & Structural features filter. This strategy led to 90% coverage and 86.5% sensitivity.

From: Bioinformatic discovery of microRNA precursors from human ESTs and introns

  GC content Core mfe Hairpin mfe Ch_ratio
Distribution 21 ~ 68 -42.5 ~ -11.2 -56.1 ~ -24.02 36 ~ 96
Reference value 30 ~ 60 -42.5 ~ -17.0 -50.0 ~ -24.02 50 ~ 96
Coverage 182/195 = 93% 193/195 = 99% 193/195 = 99% 193/195 = 99%
Total coverage 179/195 = 90% Sensitivity 179/207 = 86.5%