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Table 2 Statistics of candidates from different result sets. We started with 842,212 ESTs and 209,904 intronic sequences, within which there were originally 26 and 60 pre-miRNAs, respectively. After conservation examination, finding the target, and checking the conservation of target genes, we obtained HMDR, HMDR_Target(H), HMDR_Target(M), HMDR_Target(R), HMDR_Target(HM) and HMDR_Target(HR) sets and calculated the specificity and sensitivity for each set. HMDR are the pre-miRNA candidates conserved in all four genomes (human, mouse, dog and rat). HMDR_Target(H) represents the pre-miRNA candidates found in the HMDR set and also found to have human target genes. HMDR_Target(M) represents the pre-miRNA candidates found in HMDR set and also found to have mouse target genes. HMDR_Target(R) represents the pre-miRNA candidates found in HMDR set and also found to have rat target genes. HMDR_Target(HM) represents the pre-miRNA candidates found in HMDR set and also found to have human and mouse target genes in orthologous pairs. HMDR_Target(HR) represents the pre-miRNA candidates found in HMDR set and also found to have human and rat target genes in orthologous pairs.

From: Bioinformatic discovery of microRNA precursors from human ESTs and introns

 

EST

INTRON

SUM

miRNA Candidate Set

Our Candidate

Known miRNA

Our Candidate

Known miRNA

Our Candidate

Known miRNA

Sensitivity

Specificity

HMDR

61

17/26

147

35/60

208

52/86

60.5%

25.0%

HMDR_Target(H)

45

15/26

110

34/60

155

49/86

57.0%

31.6%

HMDR_Target(M)

45

15/26

110

34/60

155

49/86

57.0%

31.6%

HMDR_Target(R)

45

15/26

110

34/60

155

49/86

57.0%

31.6%

HMDR_Target(HM)

39

14/26

103

33/60

142

47/86

54.7%

33.1%

HMDR_Target(HR)

37

15/26

93

31/60

130

46/86

53.5%

35.4%