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Table 2 Statistics of candidates from different result sets. We started with 842,212 ESTs and 209,904 intronic sequences, within which there were originally 26 and 60 pre-miRNAs, respectively. After conservation examination, finding the target, and checking the conservation of target genes, we obtained HMDR, HMDR_Target(H), HMDR_Target(M), HMDR_Target(R), HMDR_Target(HM) and HMDR_Target(HR) sets and calculated the specificity and sensitivity for each set. HMDR are the pre-miRNA candidates conserved in all four genomes (human, mouse, dog and rat). HMDR_Target(H) represents the pre-miRNA candidates found in the HMDR set and also found to have human target genes. HMDR_Target(M) represents the pre-miRNA candidates found in HMDR set and also found to have mouse target genes. HMDR_Target(R) represents the pre-miRNA candidates found in HMDR set and also found to have rat target genes. HMDR_Target(HM) represents the pre-miRNA candidates found in HMDR set and also found to have human and mouse target genes in orthologous pairs. HMDR_Target(HR) represents the pre-miRNA candidates found in HMDR set and also found to have human and rat target genes in orthologous pairs.

From: Bioinformatic discovery of microRNA precursors from human ESTs and introns

  EST INTRON SUM
miRNA Candidate Set Our Candidate Known miRNA Our Candidate Known miRNA Our Candidate Known miRNA Sensitivity Specificity
HMDR 61 17/26 147 35/60 208 52/86 60.5% 25.0%
HMDR_Target(H) 45 15/26 110 34/60 155 49/86 57.0% 31.6%
HMDR_Target(M) 45 15/26 110 34/60 155 49/86 57.0% 31.6%
HMDR_Target(R) 45 15/26 110 34/60 155 49/86 57.0% 31.6%
HMDR_Target(HM) 39 14/26 103 33/60 142 47/86 54.7% 33.1%
HMDR_Target(HR) 37 15/26 93 31/60 130 46/86 53.5% 35.4%