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Table 3 Sensitivity test on 130 newly published pre-miRNAs. We tested the sensitivity of applying the same criteria, derived from the 207 original pre-miRNAs, on 130 newly published pre-miRNAs based on release 8.0. After the hairpin finding procedure, 116 of the 130 input pre-miRNAs were detected. We calculated the distributions of quantifiable features, namely GC content, core mfe, hairpin mfe and the ratio of core mfe to hairpin mfe. Such criteria in the Sequence & Structural features filter led to 85% sensitivity, similar to the result obtained from the test on the original 207 pre-miRNAs.

From: Bioinformatic discovery of microRNA precursors from human ESTs and introns

  GC content Core mfe Hairpin mfe Ch_ratio
Distribution 22 ~ 72 -46.1 ~ -6.8 -56.1 ~ -13.3 0.36 ~ 0.96
Reference value 30 ~ 60 -42.5 ~ -17.0 -50.0 ~ -24.02 0.50 ~ 0.96
Coverage 114/116 = 98% 112/116 = 97% 112/116 = 97% 115/116 = 99%
Coverage 110/116 = 95% Sensitivity 110/130 = 85%