Comparative analysis and integrative classification of NCI60 cell lines and primary tumors using gene expression profiling data

Table 3 Classification of non-small cell lung cancer, CNS cancer and leukemia cell lines into tumor subtypes or tumor stages.

Cell lines	No. of cell lines	Known classes	Gene feature	Classification method	LOOCV error rate	Prediction results
Lung	7	AD, SQ, COID, SCLC	4 PC	LDA	0.01	AD (NCI-H226, NCI-H460, HOP-62, HOP-92, A549, EKVX) SQ (NCI-H322M)
Lung AD	6	stage I, stage II, stage III/IV	79 genes	kNN (k = 6)	0	stage II (NCI-H226, HOP-62, HOP-92, EKVX, NCI-H460) stage III/IV (A549)
CNS	4	CG, CO	3 genes	kNN (k = 3)	0	CG (SNB-19, SNB-75, U251, SF-268)
Leukemia	6	ALL, AML, MLL	12 genes	kNN (k = 7)	0	AML (RPMI-8226, SR, K-562, MOLT-4, HL-60) ALL (CCRF-CEM)

*AD: adenocarcinoma. SQ: squamous cell carcinoma. COID: pulmonary carcinoid tumor. SCLC: small cell lung cancer. CG: classic glioblastoma. CO: classic oligodendroglioma. ALL: acute lymphoblastic leukemia. AML: acute myeloid leukemia. MLL: mixed lineage leukemia. LDA: linear discriminant analysis. kNN: k nearest neighbour. PC: principal components. LOOCV: leave-one-out cross validation.