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Table 2 Classification and nomenclature of B. pendula PR-10 sequences from our cultivars and GenBank. Indicated are the subfamily (I to V), gene designations (PR-10.01A to PR-10.05), allergen designation if the genes are known to be pollen expressed (Bet v 1.01A to Bet v 1.02C), and allele names as defined in Figure 2. Known isoforms [19] are shown, followed, between brackets, by the GenBank accession number. The tissue of origin is shown in case of mRNA-derived GenBank sequences (L = leaves, R = roots, P = pollen).

From: Seven different genes encode a diverse mixture of isoforms of Bet v 1, the major birch pollen allergen

Sub-family

Gene

Allergen

Allele (GenBank no.)*1

Known isoforms (GenBank no.)*1

Location of transcription

Sequence identity to reference sequence*2

I

PR-10.01A

Bet v 1.01A

Bet v 1.01A01.01*3 (DQ296566)

Bet v 1a = Bet v 1.0101 (X15877), - (AJ001553)

P, P

100%

   

Bet v 1.01A02.01 (DQ296567)

 

-

99.1%

   

Bet v 1.01A03.01 (DQ296568)

 

-

99.1%

    

Bet v 1.1501 (Z72429)

-

99.8%

    

Bet v 1.1502 (Z72432)

-

99.8%

    

Bet v 1.0102 (Z80098)

P

99.8%

    

Bet v 1.0103 (Z80099)

P

99.8%

    

Bet v 1.2501 (Z80101)

P

98.8%

    

Bet v 1.2801 (Z80104)

P

99.5%

    

Bet v 1.3001 (Z80106)

P

99.8%

    

- (AF124838)

-

98.6%

    

- (AJ002107)

P

99.8%

    

- (AJ002109)

P

99.3%

    

- (AJ006905)

P

99.8% *4

    

- (AJ006911)

P

98.6%

    

- (AJ006913)

P

99.5% *4

 

PR-10.01B

Bet v 1.01B

Bet v 1.01B01.01 (DQ296569)

- (AJ001552), - (AJ002106)

P, P

100%

    

Bet v 1d = Bet v 1.0401 (X77266)

P

99.3%

    

Bet v 1h = Bet v 1.0402 (X77270)

P

99.8%

    

- (AJ001551)

P

99.8%

 

PR-10.01C

Bet v 1.01C

Bet v 1.01C01.01 (DQ296570)

 

-

100%

   

Bet v 1.01C02.01 (DQ296571)

 

-

99.8%

    

Bet v 1f = Bet v 1.0601 (X77268)

P

99.8%

    

Bet v 1i = Bet v 1.0602 (X77274)

P

99.8%

    

- (AJ001557)

P

99.5%

 

PR-10.01D

Bet v 1.01D

Bet v 1.01D01.01 (DQ296572)

- (AJ001555)

P

100%

   

Bet v 1.01D02.01 (DQ296573)

 

-

99.1%

    

Bet v 1.1701 (Z72430)

-

98.4%

    

- (AF124839)

-

98.4%

II

PR-10.02A

Bet v 1.02A

Bet v 1.02A01.01 (DQ296574)

 

-

100%

   

Bet v 1.02A02.01 (DQ296575)

 

-

99.8%

    

- (AJ001554)

P

99.8%

    

- (AJ001556)

P

99.8%

 

PR-10.02B

Bet v 1.02B

Bet v 1.02B01.01 (DQ296576)

 

-

100%

   

Bet v 1.02B02.01a*5 (DQ296577)

 

-

99.3%

   

Bet v 1.02B02.01b (DQ296578)

 

-

99.3%

    

Bet v 1.1801 (Z72431)

-

99.1%

 

PR-10.02C

Bet v 1.02C

Bet v 1.02C02.01 (DQ296580)

Bet v 1k = Bet v 1.0901 (X77272)

P

100%

   

Bet v 1.02C02.02 (DQ296581)

 

-

99.8%

   

Bet v 1.02C01.01 (DQ296579)

 

-

99.8%

    

Bet v 1.20101 (Z72434)

-

99.3%

    

Bet v 1c = Bet v 1.0301 (X77265)

P

99.8%

    

Bet v 1.1901 (Z72433)

-

98.6%

    

Bet v 1m = Bet v 1.1401 (X81972)

P

99.3%

    

Bet v 1n = Bet v 1.1402 (X82028)

P

99.3%

III

PR-10.03A

-

PR-10.03A01.01 (DQ296582)

 

-

100%

   

PR-10.03A02.01 (DQ296583)

 

-

99.8%

 

PR-10.03B

-

PR-10.03B01.01 (DQ296584)

 

-

100%

   

PR-10.03B-p01*5 (DQ296586)

 

-

100%*4

 

PR-10.03B*6

 

PR-10.03B02.01 (DQ296585)

 

-

96.5%

 

PR-10.03C

-

PR-10.03C01.01 (DQ296587)

- (AJ289771)

-

100%

   

PR-10.03C02.01 (DQ296588)

 

-

99.5%

   

PR-10.03C02.02 (DQ296589)

 

-

99.3%

    

Bet v 1.1201 (X77600)

L, R

99.5%

 

PR-10.03D

-

PR-10.03D01.01 (DQ296590)

 

-

100%

   

PR-10.03D02.01 (DQ296591)

 

-

99.8%

    

Bet v 1.1101 (X77599)

L, R

99.5%

IV

PR-10.04

-

PR-10.0401.01 (DQ296592)

 

-

100%

   

PR-10.0402.01 (DQ296593)

 

-

98.9%

V

PR-10.05

-

PR-10.0501.03 (DQ296596)

Bet v1 1.1301 (X77601), - (AJ289770)

L, R

100%

   

PR-10.0501.02 (DQ296595)

 

-

99.5%

   

PR-10.0501.01 (DQ296594)

 

-

99.8%

   

PR-10.0501.04 (DQ296597)

 

-

99.8%

   

PR-10.0502.01 (DQ296598)

 

-

99.8%

  1. *1 The known mRNA-derived GenBank sequences contain no intron, while the new gDNA sequences do, aiding in the gene identification.
  2. *2 The upper most allele was taken as a reference sequence, identities are calculated for an aligned stretch of 425 bp from base 28 to 452 of the consensus.
  3. *3 The last two numerals indicate silent mutations (see Results section for further explanation of the nomenclature)
  4. *4 These sequences contain an indel; Sequence identity is calculated excluding the indel.
  5. *5 Pseudogene allele.
  6. *6In vivo recombination.