Predicting candidate genes for human deafness disorders: a bioinformatics approach

BMC Genomics

Table 5 List of candidates for various deafness loci.

Loci	Location	Candidates	Loci	Location	Candidates
DFNA7	1q21–q23	ATP1B1	DFNB5	14q12	**
		F5	DFNB13	7q34–36	SLC37A3
		MYOC	DFNB17	7q31	WNT2
		SLC19A2	DFNB19	18p11	LAMA1
		POU2F1	DFNB20	11q25–qter	KCNJ1
DFNA16	2q24	*			TECTA
DFNA18	3q22	**			SLC37A2
DFNA21	6p21	*	DFNB27	2q23–q31	ITGA6
DFNA23	14q21–q22	**			SP3
DFNA25	12q21–24	HAL	DFNB28	22q13	KCNJ4
		SLC25A3			MT
		IGF1			SOX10
DFNA27	4q12	HAT	DFNB32	1p13.3–22.1	COL11A1
		KDR/VEGFR2			DR1
DFNA30	15q25–26	**			F3
DFNA31	6p21.3	TNF	DFNB33	9q34.3	TUBB2
		POU5F1			SLC34A3
DFNA34	1q44	**	DFNB35	14q24.1–24.3	NUMB
DFNA42	5q31.1	FGF1			FOS
		GFRA3	DFNB38	6q26–q27	QK1
		IK	DFNB39	7q11.22–q21.12	POR
		PCDH1	DFNB40	22q	CRYBB2
		DIAPH1			SLC25A1
		POU4F3			TBX1
DFNA47	9p21–22	**

*The chromosomal regions for DFNA16 and DFNA21 code for 7 and 9 genes, respectively. However, none of these genes were listed in the mouse or human inner ear databases. The candidates as described in the text are based on their functional significance.
**The chromosomal regions for DFNA18, DFNA23, DFNA30, DFNA34, DFNA47 and DFNB5 code for a substantial number of genes. A small fraction of these genes are listed in human and mouse inner ear databases as shown in Table 6. Furthermore, no hits were scored by the protein interaction approach. Therefore the genes scoring hits in the ear databases may be considered as candidates and prioritized based on their function. Some of these priority candidates are described in the text.

ISSN: 1471-2164