Figure 2

Comparison of the organization of coding regions of murine and human FAK genes. The correspondance is shown between the domain organization of FAK protein and the structure of the murine and human FAK genes. Dark and striped boxes denote constitutive and conserved alternative exons, respectively. White boxes denote species-specific exons or additional sequences reported in transcripts (see Table 1 for details). Translation initiation codon (ATG) for FAK and FRNK are indicated by arrows. Exons 18a and 23a are specific of primate genomes. FERM: four-point-one, ezrin, radixin, moesin; PR: proline-rich; FAT: focal adhesion targeting. The positions of autophosphorylated Tyr-397, boxes 28, 6, 7 and PWR are indicated.