Comparative evolutionary genomics of the HADH2 gene encoding Aβ-binding alcohol dehydrogenase/17β-hydroxysteroid dehydrogenase type 10 (ABAD/HSD10)

Table 2 Results of the gene level approach (PAML) applied in eutherian mammal HADH2 genes

NOTE. – In M1 and M2 models, p₀, p₁, and p_s are the proportions of codons estimated to each ω class. In M7 and M8 models, p and q are the parameters of the beta distribution and p_s is the proportion of codon sites assigned to the positive selection class. M0 assumes a constant ω value while the free-ratio model assumes an independent ω ratio for each branch. Two-ratio model assumes a different ω ratio for the foreground branch (branch separating human and chimpanzee from orangutan) and background branches. 2Δl is the log likelihood ratio statistic and l is the log likelihood value estimated for each model. No sites were identified under positive selection within the 95% confidence level by models M2a and M8; sites 5, 14, 49, 56, 57, 106, 59, 98, 103, 123, 239 were identified under model M8 with a P < 0.75.

ISSN: 1471-2164