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Table 3 Computational identification of putative transcription factor binding sites. Species include rainbow trout (UCP2A Om, UCP2B Om) zebrafish (UCP2 Dr), mouse (UCP2 Mm) and human UCP2 (UCP2 Hs) promoter regions using TFSearch engine version 1.3. Number of representations of each transcription factor binding sites are indicated and "-"indicates less than 2 binding sites.

From: Genomic structure and expression of uncoupling protein 2 genes in rainbow trout (Oncorhynchus mykiss)

Genes

ADR1

AML-1a

CAP

CdxA

CREB

HSF

MZF1

Nkx2

SRY

USF

UCP2A Om

2

-

2

9

-

5

-

-

-

-

UCP2B Om

2

-

2

6

3

9

-

2

4

-

UCP2 Dr

4

-

4

18

-

24

-

3

4

-

UCP2 Mm

26

2

26

2

-

21

4

2

2

2

UCP2 Hs

20

5

20

3

-

19

3

3

5

-

  1. ADR1: Alcohol Dehydrogenase Gene Regulator 1 (S. cerevisiae), activator.
  2. AML-1a: Acute Myeloid Leukemia 1; (human); may act as a negative regulator.
  3. Cap: cap signal for transcription initiation signal (vertebrates), activator.
  4. CdxA: chick; Chicken CHox-cad gene for caudal homologue, activator.
  5. CREB: Cyclic-AMP Response Element-Binding Protein, transactivator.
  6. HSF: Heat Shock Transcription Factor (Drosophila), activator.
  7. MZF1: Myeloid Zinc Finger protein MZF1 (human); possibly involved in hemopoietic development.
  8. Nkx2: murine homeobox gene (mouse) modest activator probably important for myocardial development.
  9. SRY: Sex-determining Region Y gene product (human, mouse).
  10. USF: Upstream Stimulatory Transcription, activator (mouse).