Figure 3

Phylogenetic analysis of KIR genes in primates. Sequences for human (hs), common chimpanzee (pt), gorilla (gg), rhesus monkey (mm) and common marmoset (cj) have been grouped according to their lineages: lineage 1A (yellow squares), lineage 1B (green squares), lineage II (green triangles), lineage III (pink diamonds), lineage IV (blue circles) and the newly proposed lineage 0 encompassing the novel KIR3DL0 genes is marked by red squares. Lineage V genes were excluded from the analysis owing to their variable phylogenetic clustering and varied exon organization [8]. Phylogenetic analysis was carried out on protein sequences that were edited manually to maximise the alignment between corresponding Ig domains, as well as the stem, TM and cytoplasmic tail.