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Table 3 The proportions of A→G and C→T FFD substitutions corrected by codon compositions

From: Strand bias in complementary single-nucleotide polymorphisms of transcribed human sequences: evidence for functional effects of synonymous polymorphisms

FFD SNPs

Substitution type

Observed number

Codon type*

Codon count

Corrected proportion

χ2 test

Asymmetry ratio (95%CI)

Non-CpG site

A→G

148

NDA

265,987

0.350

χ2 = 13.6, v = 1, p < 0.001

A→G vs. T→C 1.56 (1.23, 1.97)

 

T→C

127

NNT|H

355,455

0.225

  
 

G→A

207

NDG

689,990

0.189

χ2 = 6.2, v = 1, p = 0.013

C→T vs. G→A 1.25 (1.05, 1.49)

 

C→T

307

NNC|H

818,126

0.236

  

CpG site

A→G

316

NCA

309,513

0.099

χ2 = 26.0, v = 1, p < 0.001

A→G vs. T→C 1.63 (1.35, 1.97)

 

T→C

163

NNT|G

259,869

0.061

  
 

G→A

654

NCG

132,113

0.479

χ2 = 21.3, v = 1, p < 0.001

C→T vs. G→A 0.75 (0.67, 0.85)

 

C→T

452

NNC|G

121,011

0.361

  
  1. * N represents A or C or G or T, D represents A or G or T, and H represents A or C or T