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Table 3 The proportions of A→G and C→T FFD substitutions corrected by codon compositions

From: Strand bias in complementary single-nucleotide polymorphisms of transcribed human sequences: evidence for functional effects of synonymous polymorphisms

FFD SNPs Substitution type Observed number Codon type* Codon count Corrected proportion χ2 test Asymmetry ratio (95%CI)
Non-CpG site A→G 148 NDA 265,987 0.350 χ2 = 13.6, v = 1, p < 0.001 A→G vs. T→C 1.56 (1.23, 1.97)
  T→C 127 NNT|H 355,455 0.225   
  G→A 207 NDG 689,990 0.189 χ2 = 6.2, v = 1, p = 0.013 C→T vs. G→A 1.25 (1.05, 1.49)
  C→T 307 NNC|H 818,126 0.236   
CpG site A→G 316 NCA 309,513 0.099 χ2 = 26.0, v = 1, p < 0.001 A→G vs. T→C 1.63 (1.35, 1.97)
  T→C 163 NNT|G 259,869 0.061   
  G→A 654 NCG 132,113 0.479 χ2 = 21.3, v = 1, p < 0.001 C→T vs. G→A 0.75 (0.67, 0.85)
  C→T 452 NNC|G 121,011 0.361   
  1. * N represents A or C or G or T, D represents A or G or T, and H represents A or C or T