Figure 5

Relative expression levels of bound genes in low and high activity experiments. Fold-changes in expression levels were normalized to the standard deviation so that a Z-value of 1 corresponds to one standard deviation. Small points show the values for the 5000+ genes analyzed in each experiment. Large dots represent the 54 genes that are significantly bound and expressed according to some combination of low and high activity expression and ChIP data. Note that an estimate of statistical significance was used to identify differentially expressed genes, not the fold-change Z-value shown here. Gene and labels shown in red are the seven genes on the committed pathway to leucine and valine biosynthesis. Genes and labels shown in blue are annotated as organic acid transporters and are described in the text. The label "YOL155C" indicates a gene that is bound by Leu3 and is exceptionally strongly affected at both low and high activities, but which has no known function.