Gene order data from a model amphibian (Ambystoma): new perspectives on vertebrate genome structure and evolution

Table 2 Distribution of human/Ambystoma orthologies across human chromosomes

Human	Annotated	Human/Ambystoma Orthologies
Chromosome	Genes^a	Observed	Expected^b	Deviation^c	χ²	p
HSA1	2,580	47	33.3	+	5.67	0.017
HSA2	1,742	16	22.5	-	1.86	0.173
HSA3	1,378	21	17.8	+	0.59	0.443
HSA4	1,017	6	13.1	-	3.86	0.050
HSA5	1,188	10	15.3	-	1.85	0.174
HSA6	1,385	11	17.9	-	2.63	0.105
HSA7	1,367	21	17.6	+	0.65	0.421
HSA8	927	12	12	+	0.00	0.989
HSA9	1,069	12	13.8	-	0.23	0.631
HSA10	983	8	12.7	-	1.72	0.189
HSA11	1,692	15	21.8	-	2.13	0.145
HSA12	1,261	28	16.3	+	8.48	0.004
HSA13	491	3	6.3	-	1.75	0.186
HSA14	1,173	10	15.1	-	1.74	0.188
HSA15	884	11	11.4	-	0.01	0.906
HSA16	1,031	16	13.3	+	0.55	0.458
HSA17	1,354	29	17.5	+	7.63	0.006
HSA18	400	4	5.2	-	0.26	0.610
HSA19	1,584	28	20.4	+	2.81	0.094
HSA20	710	11	9.2	+	0.37	0.542
HSA21	337	4	4.3	-	0.03	0.869
HSA22	693	4	8.9	-	2.73	0.099
HSAX	1,125	13	14.5	-	0.16	0.693

^aThe number of genes that were assigned to each human chromosome (Build 35.1) [25].
^bThe expected number of human salamander orthologies is based on random sampling from the human genome. This number is calculated as the proportion of genes that occur on a given human chromosome multiplied by the entire number of human/Ambystoma orthologies that were identified (N = 340). A single HSAY orthology is excluded from this table.
^c"+" designates a positive deviation from the expected number,"-" designates a negative deviation from the expected number.

ISSN: 1471-2164