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Table 4 The top 25 genes exhibiting increased mRNA abundance 2 hours post activation.

From: Development and validation of a bovine macrophage specific cDNA microarray

Clone E value Accession No. Gene Symbol Gene Fold Increase FDRmax P value
pIL8 0.0 NM_173925 IL8 Interleukin 8 40.00 1.23E-18 4.91E-22
MARC_3BOV_60P17 0.0 NM_174299 CXCL2 Chemokine (C-X-C motif) ligand 2 (GROβ/MIP2A) 38.20 1.25E-15 1.24E-18
C0006019e20 0.0 NM_181015 PRNP Prion protein 28.13 1.05E-20 2.08E-24
MARC_1BOV_101M3 0.0 NM_174263 CCL20 Chemokine (C-C motif) ligand 20 (MIP3A) 25.81 3.14E-10 3.56E-12
MARC_1BOV_94L3 0.0 NM_174300 CXCL6 Chemokine (C-X-C motif) ligand 6 22.91 1.72E-11 1.23E-13
C0005209b8 6.00E-72 XM_612426 CCRN4L CCR4 carbon catabolite repression 4-like 20.49 1.64E-11 1.14E-13
C0006018n14 0.0 NM_174006 CCL2 Chemokine (C-C motif) ligand 2 (MCP-1) 19.45 1.32E-07 4.19E-09
C0005204j16 0.0 XM_864683 CXCL3 Chemokine (C-X-C motif) ligand 3 (GROγ/MIP2b) 18.16 1.20E-13 3.40E-16
C0006020d11 0.0 XM_865242 ZFAND2A Zinc finger, AN1-type domain 2A 17.61 1.10E-14 1.31E-17
C0006011e13 e-179 CK976904 - EST 16.71 3.10E-08 8.41E-10
C0005208k22 e-167 NM_173198 NR4A3 Nuclear receptor subfamily 4, group A, member 3 15.65 2.39E-12 1.14E-14
C0006020e20 0.0 CB419326 - EST 14.07 9.10E-12 5.60E-14
MARC_3BOV_36F6 0.0 NM_175827 CCL5 Chemokine (C-C motif) ligand 5 (RANTES) 13.84 2.90E-12 1.47E-14
C0006018g13 0.0 XM_611249 SLCO4A1 Solute carrier organic anion transporter family, member 4A1 13.79 4.62E-10 5.89E-12
MARC_1BOV_72M12 0.0 XM_866821 CXCL10 Chemokine (C-X-C motif) ligand 10 (IP10) 13.71 1.09E-05 6.09E-07
C0005199c13 0.0 AY248754 TNFAIP3 TNF-alpha induced protein 3 13.48 2.34E-08 5.90E-10
C0006015e11 0.0 XM_881561 PMAIP1 Phorbol-12-myristate-13-acetate-induced protein 1 12.99 1.95E-12 8.90E-15
C0005202i8 0.0 XM_583725 APOBEC3A Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 12.96 1.20E-13 2.97E-16
MARC_3BOV_120N21 0.0 NM_174028 CSF3 Colony stimulating factor 3 (granulocyte) (G-CSF) 12.76 8.11E-11 7.73E-13
C0006015n15 2.00E-69 NM_002748 MAPK6 Mitogen-activated protein kinase 6 (erk-3) 12.64 8.88E-12 5.11E-14
C0006016h15 0.0 XM_613370 RGS1 Regulator of G-protein signalling 1 12.59 5.10E-09 1.00E-10
C0006013p15 e-158 CB534198 - EST 12.59 1.93E-11 1.50E-13
C0005202d9 0.0 XM_870158 ANKRD22 Ankyrin repeat domain 22 11.99 6.36E-17 3.79E-20
MARC_1BOV_57B12 0.0 NM_174348 ICAM1 Intercellular adhesion molecule 1 (CD54) 11.40 6.40E-10 9.15E-12
C0005206b23 3.00E-82 NM_001432 EREG Epiregulin 10.98 1.98E-07 6.61E-09
  1. Summary of the top 25 genes exhibiting increased mRNA abundance 2 hours post activation, including clone name, accession number, e-value and identity of the best BLAST match and average fold change. The P and FDRmax values denote the probability from the moderated t-test and the Benjamini and Hochberg false discovery rate values respectively from the analysis of the resting cell values compared to the average activated sample values (Pre v Post).