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Table 3 Indels within coding regions.

From: Genome sequence alterations detected upon passage of Burkholderia mallei ATCC 23344 in culture and in mammalian hosts

Isolate

Indel

Reference Protein Length

Frameshift Length (bp change)

Query Protein Length

Locus

Annotation

Lab Culture

1

638 aa

29 aa (+C)

No stop codonb

BMAA1927

Hypothetical Protein

 

2

154 aa

50 aa (-T)

75 aa

BMA1435

Hypothetical Protein

 

3

145 aa

64 aa (-G)

85 aa

BMA2147

N utilization substance protein B

 

4

711 aa

586 aa (+A)

No stop codonb

BMA2914

Oxidoreductase

Mouse spleen

1a

942 aa

No

938 aa

BMAA0680

Penicillin-binding protein

 

2

357 aa

13 aa (+G)

321 aa

BMA0161

Rod shape-determining protein MreC

Horse Lung

1

787 aa

525 aa (+G)

721 aa

BMAA0367

Acetyltransferase, GNAT family

 

2a

136 aa

No

138 aa

BMAA0623

Hypothetical protein

 

3a

120 aa

66 aa

100 aa

BMA2996

Hypothetical protein

Human Liver

1a

659 aa

52 aa

62 aa

BMAA0729

Hypothetical protein

 

2a

122 aa

69 aa

85 aa

BMA3028

Conserved domain protein

 

3

No translation

49 aa (+A)

361 aa

BMAA1903

Conserved hypoth. protein

 

4

685 aa

164 aa (+T)

328 aa

BMA0685

Vit. B12 receptor BtuB, putative

Human Blood

1a

122 aa

69 aa

85 aa

BMA3028

Conserved domain protein

 

2a

193 aa

157 aa

No stop codonb

BMAA0789

Hypothetical protein

 

3

No translation

49 aa (+A)

361 aa

BMA1903

Conserved hypoth. protein

  1. aCoding region indels within SSRs. Mouse spleen 1a: repeat unit AACACCGAACCG; Horse lung 2a: repeat unit GGTGCC, 3a: repeat unit GAGCGGT; Human liver 1a : repeat unit CGAGTCAT extra copy in reference, 2a: repeat unit GCCGATT extra copy in query; Human blood 1a: GCCGATT extra copy in query, 2a: GCGCCTC two extra copies in reference.
  2. bReference protein lost the stop codon at the original position due to the frameshift; query protein has a new stop codon in a different position.