Promoter analysis of PEDF. A. Alignment of human, chimpanzee, mouse and rat PEDF promoter sequences. Alignment of the human and chimpanzee sequences show extensive homology, as do the mouse and rat sequences (homologous regions shown in grey). Very few conserved regions are seen when the human and mouse or human and rat sequences are aligned. The largest region of homology is the 200 bp upstream of the transcription start site. Right end of each line bar represents transcription initiation sites. B. Sequence comparison of 200 bp proximal region from human and mouse promoters. Star (*) shows conservation residuals. The location of each transcription factor binding site is indicated by lines.