STAT1 binding in response to IFN-γ is positively and negatively correlated with RNApolII binding. (A – N) Levels of differential STAT1 binding in response to IFN-γ (ΔSTAT1; black line) are plotted for locations within the ENCODE region where STAT1 binding sites (blue circles) were identified. Levels of RNApolII binding in non-stimulated HeLaS3 cells are shown in green ("0" corresponds to average RNApolII binding across the ENCODE region). Black boxes indicate the locations of exons; connecting lines indicate intronic regions; arrowheads within introns indicate the direction of transcription. Raw data were obtained from Rozowsky et al' s tiling array analysis of STAT1 binding in response to IFN-γ , and Bieda et al.'s tiling array of RNApolII binding in non-stimulated cells .