Table 3 Overview of representative hits above 0.8
From: Integration of curated databases to identify genotype-phenotype associations
Lab/Condition | Cog/Protein Name | Correlation | P-value | Protein Function |
|---|---|---|---|---|
B01/Gram-negative | COG0763/Lipid A disaccharide synthetase | 0.95 | 1.71E-09 | Involved in Lipid A biosynthesis [26–28] |
| Â | COG0774/UDP-3-O-acyl-N-acetylglucosamine deacetylase | 0.95 | 1.71E-09 | Involved in Lipid A biosynthesis [29] [27,30] |
| Â | COG1212/CMP-2-keto-3-deoxyoctulosonic acid synthetase | 0.95 | 1.71E-09 | Involved in lipopolysaccharide biosynthesis [31] |
| Â | COG2877/3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase | 0.95 | 1.71E-09 | Involved in lipopolysaccharide biosynthesis [32] |
| Â | COG0848/Biopolymer transport protein | 0.95 | 1.71E-09 | Outer membrane transporters [33,34] |
| Â | COG2885/Outer membrane protein | 0.84 | 2.46E-09 | Outer membrane protein [35] |
B02/Gram-positive | COG3764/Sortase | 1.0 | 2.59E-08 | Plasma membrane protein [36] |
| Â | COG2344/AT-rich DNA-binding protein | 0.92 | 7.77E-07 | Transcriptional regulator [37] |
| Â | COG3966/Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) | 0.84 | 1.2E-05 | Cell wall and membrane component protein [38] |
B29/Growth on MacConkey Agar | COG4206/Outer membrane cobalamin receptor protein | 0.99 | 8.04E-09 | Outer membrane protein [39] |
| Â | COG4787/Flagellar basal body rod protein | 0.97 | 2.33E-07 | Periplasmic protein [40] |
| Â | COG3166/Tfp pilus assembly protein PilN | 0.83 | 9.77E-06 | Outer membrane proteins [41] |
B30/Oxidase | COG3278/Cbb3-type cytochrome oxidase, subunit 1 | 0.85 | 7.84E-06 | Oxidase protein subunit |
B30/Oxidase | COG2993/Cbb3-type cytochrome oxidase, cytochrome c subunit | 0.85 | 7.84E-06 | Oxidase protein subunit |
B31/Catalase | COG0753/Catalase | 0.97 | 7.69E-06 | Peroxisomal Marker Enzyme |
| Â | COG1607/Acyl-CoA hydrolase | 0.97 | 7.69E-06 | Enzyme involved in lipid metabolism [13] |
FAC/L-Arabinose | COG3717/5-keto 4-deoxyuronate isomerase | 0.97 | 3.95E-05 | Enzyme involved in carbohydrate metabolism [14,15] |
FAM/D-Mannose | COG0246/Mannitol-1-phosphate/altronate dehydrogenases | 0.85 | 4.68E-05 | Oxidizes mannitol to mannose [42] |
FAT/Trehalose | COG2182/Maltose-binding periplasmic proteins/domains | 0.94 | 3.4E-05 | Maltose-related protein [16] |
G03/Motile | COG0835/Chemotaxis signal transduction protein | 0.94 | 4.93E-09 | Chemotaxis-related protein |
| Â | COG1345/Flagellar capping protein | 0.94 | 4.93E-09 | Flagella-related protein |
| Â | COG1516/Flagellin-specific chaperone FliS | 0.94 | 4.93E-09 | Flagella-related protein |