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Table 2 Biological processes significantly affected (Fisher exact test p value < 0.05) by BaP in MCF-7 cells as determined by EASE

From: Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2

MCF-7 time and concentration down-regulated genes MCF-7 time and concentration up-regulated genes
Biological Process Probability Biological Process Probability
regulation of actin filament length 4.9E-06 water-soluble vitamin metabolism 3.7E-03
actin cytoskeleton organization and biogenesis 1.8E-04 sodium\:calcium exchange 6.2E-03
actin filament-based process 2.4E-04 pentose-phosphate shunt, oxidative branch 6.2E-03
regulation of actin polymerization and/or depolymerization 4.0E-04 glyoxylate cycle 6.2E-03
one-carbon compound metabolism 4.6E-04 glyoxylate metabolism 6.2E-03
cell organization and biogenesis 8.2E-04 vitamin metabolism 8.6E-03
nucleosome assembly 9.0E-04 amino acid transport 1.2E-02
carboxylic acid metabolism 1.5E-03 thiamin and derivative metabolism 1.2E-02
organic acid metabolism 1.6E-03 embryonic eye morphogenesis 1.2E-02
actin polymerization and/or depolymerization 2.2E-03 solute, solute exchange 1.2E-02
amine metabolism 2.4E-03 thiamin metabolism 1.2E-02
establishment and/or maintenance of chromatin architecture 3.2E-03 internal protein amino acid acetylation 1.2E-02
DNA packaging 4.3E-03 eye morphogenesis (sensu Vertebrata) 1.2E-02
chromatin assembly/disassembly 4.7E-03 eye morphogenesis (sensu Mammalia) 1.2E-02
amino acid metabolism 4.7E-03 isocitrate metabolism 1.2E-02
cytoskeleton organization and biogenesis 5.8E-03 amine/polyamine transport 1.3E-02
chromosome organization and biogenesis (sensu Eukarya) 6.4E-03 regulation of CDK activity 1.4E-02
muscle maintenance 6.5E-03 negative regulation of cell proliferation 1.6E-02
negative regulation of actin filament polymerization 6.5E-03 GPI anchor biosynthesis 1.8E-02
anion homeostasis 6.5E-03 GPI anchor metabolism 1.8E-02
monovalent inorganic anion homeostasis 6.5E-03 regulation of survival gene product activity 1.8E-02
asparagine metabolism 6.5E-03 negative regulation of survival gene product activity 1.8E-02
sequestering of actin monomers 6.5E-03 G2/M transition of mitotic cell cycle 1.9E-02
asparagine biosynthesis 6.5E-03 carboxylic acid transport 2.1E-02
nuclear organization and biogenesis 6.8E-03 organic acid transport 2.1E-02
amino acid and derivative metabolism 7.8E-03 apoptotic mitochondrial changes 2.4E-02
cell growth 1.0E-02 germ-cell development 2.4E-02
myelination 1.3E-02 protein amino acid acetylation 2.4E-02
isoleucyl-tRNA aminoacylation 1.3E-02 G1/S transition of mitotic cell cycle 2.5E-02
threonyl-tRNA aminoacylation 1.3E-02 NADPH metabolism 3.0E-02
regulation of actin filament polymerization 1.3E-02 NADPH regeneration 3.0E-02
organelle organization and biogenesis 1.7E-02 CTP biosynthesis 3.0E-02
salivary gland morphogenesis 1.9E-02 UTP metabolism 3.0E-02
salivary gland development 1.9E-02 UTP biosynthesis 3.0E-02
folic acid and derivative biosynthesis 2.6E-02 pentose-phosphate shunt 3.0E-02
glycine metabolism 2.6E-02 CTP metabolism 3.0E-02
cytoplasm organization and biogenesis 2.6E-02 synaptic transmission\, cholinergic 3.0E-02
actin filament polymerization 3.2E-02 eye morphogenesis 3.0E-02
folic acid and derivative metabolism 3.2E-02 pyrimidine ribonucleoside triphosphate metabolism 3.0E-02
regulation of cell growth 3.8E-02 pyrimidine ribonucleoside triphosphate biosynthesis 3.0E-02
aspartate family amino acid biosynthesis 3.8E-02 pyrimidine ribonucleotide biosynthesis 3.6E-02
L-serine metabolism 3.8E-02 GTP metabolism 3.6E-02
nerve ensheathment 4.4E-02 GTP biosynthesis 3.6E-02
negative regulation of cell adhesion 4.4E-02 pyrimidine ribonucleotide metabolism 3.6E-02
nerve maturation 4.4E-02 nicotinamide metabolism 3.6E-02
glycosphingolipid biosynthesis 4.4E-02 pyrimidine nucleoside triphosphate metabolism 3.6E-02
tRNA aminoacylation for protein translation 4.6E-02 phosphoinositide biosynthesis 3.6E-02
tRNA aminoacylation 4.6E-02 oncogenesis 3.8E-02
amino acid activation 4.6E-02 DNA repair 4.2E-02
tRNA modification 4.7E-02 covalent chromatin modification 4.2E-02
   phosphoinositide metabolism 4.2E-02
   histone deacetylation 4.2E-02
   pyridine nucleotide metabolism 4.2E-02
   heavy metal sensitivity/resistance 4.2E-02
   nerve-nerve synaptic transmission 4.2E-02
   histone modification 4.2E-02
   aldehyde metabolism 4.2E-02
   protein modification 4.3E-02
   main pathways of carbohydrate metabolism 4.5E-02
   obsolete biological process 4.7E-02
   prostanoid metabolism 4.8E-02
   embryonic development (sensu Vertebrata) 4.8E-02
   lipoprotein biosynthesis 4.8E-02
   insulin receptor signaling pathway 4.8E-02
   prostaglandin metabolism 4.8E-02
   embryonic development (sensu Mammalia) 4.8E-02
   protein lipidation 4.8E-02