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Table 2 Biological processes significantly affected (Fisher exact test p value < 0.05) by BaP in MCF-7 cells as determined by EASE

From: Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2

MCF-7 time and concentration down-regulated genes

MCF-7 time and concentration up-regulated genes

Biological Process

Probability

Biological Process

Probability

regulation of actin filament length

4.9E-06

water-soluble vitamin metabolism

3.7E-03

actin cytoskeleton organization and biogenesis

1.8E-04

sodium\:calcium exchange

6.2E-03

actin filament-based process

2.4E-04

pentose-phosphate shunt, oxidative branch

6.2E-03

regulation of actin polymerization and/or depolymerization

4.0E-04

glyoxylate cycle

6.2E-03

one-carbon compound metabolism

4.6E-04

glyoxylate metabolism

6.2E-03

cell organization and biogenesis

8.2E-04

vitamin metabolism

8.6E-03

nucleosome assembly

9.0E-04

amino acid transport

1.2E-02

carboxylic acid metabolism

1.5E-03

thiamin and derivative metabolism

1.2E-02

organic acid metabolism

1.6E-03

embryonic eye morphogenesis

1.2E-02

actin polymerization and/or depolymerization

2.2E-03

solute, solute exchange

1.2E-02

amine metabolism

2.4E-03

thiamin metabolism

1.2E-02

establishment and/or maintenance of chromatin architecture

3.2E-03

internal protein amino acid acetylation

1.2E-02

DNA packaging

4.3E-03

eye morphogenesis (sensu Vertebrata)

1.2E-02

chromatin assembly/disassembly

4.7E-03

eye morphogenesis (sensu Mammalia)

1.2E-02

amino acid metabolism

4.7E-03

isocitrate metabolism

1.2E-02

cytoskeleton organization and biogenesis

5.8E-03

amine/polyamine transport

1.3E-02

chromosome organization and biogenesis (sensu Eukarya)

6.4E-03

regulation of CDK activity

1.4E-02

muscle maintenance

6.5E-03

negative regulation of cell proliferation

1.6E-02

negative regulation of actin filament polymerization

6.5E-03

GPI anchor biosynthesis

1.8E-02

anion homeostasis

6.5E-03

GPI anchor metabolism

1.8E-02

monovalent inorganic anion homeostasis

6.5E-03

regulation of survival gene product activity

1.8E-02

asparagine metabolism

6.5E-03

negative regulation of survival gene product activity

1.8E-02

sequestering of actin monomers

6.5E-03

G2/M transition of mitotic cell cycle

1.9E-02

asparagine biosynthesis

6.5E-03

carboxylic acid transport

2.1E-02

nuclear organization and biogenesis

6.8E-03

organic acid transport

2.1E-02

amino acid and derivative metabolism

7.8E-03

apoptotic mitochondrial changes

2.4E-02

cell growth

1.0E-02

germ-cell development

2.4E-02

myelination

1.3E-02

protein amino acid acetylation

2.4E-02

isoleucyl-tRNA aminoacylation

1.3E-02

G1/S transition of mitotic cell cycle

2.5E-02

threonyl-tRNA aminoacylation

1.3E-02

NADPH metabolism

3.0E-02

regulation of actin filament polymerization

1.3E-02

NADPH regeneration

3.0E-02

organelle organization and biogenesis

1.7E-02

CTP biosynthesis

3.0E-02

salivary gland morphogenesis

1.9E-02

UTP metabolism

3.0E-02

salivary gland development

1.9E-02

UTP biosynthesis

3.0E-02

folic acid and derivative biosynthesis

2.6E-02

pentose-phosphate shunt

3.0E-02

glycine metabolism

2.6E-02

CTP metabolism

3.0E-02

cytoplasm organization and biogenesis

2.6E-02

synaptic transmission\, cholinergic

3.0E-02

actin filament polymerization

3.2E-02

eye morphogenesis

3.0E-02

folic acid and derivative metabolism

3.2E-02

pyrimidine ribonucleoside triphosphate metabolism

3.0E-02

regulation of cell growth

3.8E-02

pyrimidine ribonucleoside triphosphate biosynthesis

3.0E-02

aspartate family amino acid biosynthesis

3.8E-02

pyrimidine ribonucleotide biosynthesis

3.6E-02

L-serine metabolism

3.8E-02

GTP metabolism

3.6E-02

nerve ensheathment

4.4E-02

GTP biosynthesis

3.6E-02

negative regulation of cell adhesion

4.4E-02

pyrimidine ribonucleotide metabolism

3.6E-02

nerve maturation

4.4E-02

nicotinamide metabolism

3.6E-02

glycosphingolipid biosynthesis

4.4E-02

pyrimidine nucleoside triphosphate metabolism

3.6E-02

tRNA aminoacylation for protein translation

4.6E-02

phosphoinositide biosynthesis

3.6E-02

tRNA aminoacylation

4.6E-02

oncogenesis

3.8E-02

amino acid activation

4.6E-02

DNA repair

4.2E-02

tRNA modification

4.7E-02

covalent chromatin modification

4.2E-02

  

phosphoinositide metabolism

4.2E-02

  

histone deacetylation

4.2E-02

  

pyridine nucleotide metabolism

4.2E-02

  

heavy metal sensitivity/resistance

4.2E-02

  

nerve-nerve synaptic transmission

4.2E-02

  

histone modification

4.2E-02

  

aldehyde metabolism

4.2E-02

  

protein modification

4.3E-02

  

main pathways of carbohydrate metabolism

4.5E-02

  

obsolete biological process

4.7E-02

  

prostanoid metabolism

4.8E-02

  

embryonic development (sensu Vertebrata)

4.8E-02

  

lipoprotein biosynthesis

4.8E-02

  

insulin receptor signaling pathway

4.8E-02

  

prostaglandin metabolism

4.8E-02

  

embryonic development (sensu Mammalia)

4.8E-02

  

protein lipidation

4.8E-02