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Table 1 ToxArray™ data normalized using EC: Overall adjusted p after exposure to PB and fold changes (relative to Control) and pairwise p-values at each dose for each gene (probe) that showed differential expression.

From: Novel design and controls for focused DNA microarrays: applications in quality assurance/control and normalization for the Health Canada ToxArray™

    Control versus 100 mg/kg Control versus 10 mg/kg Control versus 1 mg/kg James-Stein F-Test
Gene(probe) Name> Full name GenBank Fold change Pairwise P-value Fold change Pairwise P-value Fold change Pairwise P-value Overall P-value
Cyp2b9 cytochrome P450, 2b9, phenobarbitol inducible, type a, NM_010000 8.29 0.0000 3.22 0.0000 1.16 0.8087 0.0000
Cyp2b10 Cytochrome P450, 2b10, phenobarbitol inducible, type b NM_009998 5.10 0.0000 2.95 0.0000 -1.08 0.8437 0.0000
Gdf15 growth differentiation factor 15 NM_011819 2.83 0.0000 1.25 0.3499 1.07 0.8667 0.0000
Gstm3 glutathione S- transferase mu 3 (EC 2.5.1.18) J03953 2.16 0.0000 1.04 0.8458 1.30 0.4200 0.0000
Lpin1 lipin 1, alias fatty liver dystrophy NM_015763 -1.94 0.0009 -1.18 0.3932 -1.08 0.8437 0.0039
Gadd45b growth arrest and DNA-damage-inducible 45 beta NM_008655 1.92 0.0000 1.08 0.6595 -1.13 0.7038 0.0000
Gadd45a growth arrest and DNA damage inducible NM_007836 1.66 0.0003 1.20 0.2245 -1.24 0.4200 0.0000
Por NADPH cytochrome p450 oxidoreductase NM_008898 1.66 0.0806 1.22 0.3847 1.04 0.9392 0.0402
Tieg1 TGFB inducible early growth response 1 NM_013692 -1.64 0.0011 -1.23 0.1983 -1.21 0.5440 0.0062
Gstm1 glutathione S-transferase mu 1 NM_010358 1.63 0.2258 -1.14 0.6339 -1.03 0.9622 0.0377
sult1c2 sulfotransferase family 1C, member 2 NM_026935 1.55 0.0044 1.16 0.3501 1.21 0.5440 0.0350
AhR rat Ah receptor NM_013464 1.48 0.0423 -1.05 0.7919 -1.12 0.7389 0.0039
Chk choline kinase NM_013490 -1.45 0.0041 -1.31 0.0876 1.02 0.9443 0.0039
Adcy6 adenylate cyclase 6 NM_007405 -1.43 0.0003 -1.20 0.1165 -1.05 0.7925 0.0004
Bhmt betaine homocysteine methyl transferase NM_016668 -1.40 0.2598 -1.16 0.4362 1.19 0.6392 0.0385
gstm2 glutathione S-transferase, mu 2 NM_008183 1.39 0.0313 -1.10 0.4647 -1.01 0.9754 0.0054
Dusp6 dual specificity phosphatase 6 NM_026268 1.39 0.0852 1.23 0.2007 -1.07 0.8288 0.0181
Lbp Lipopolysaccharide binding protein NM_008489 1.39 0.0104 1.15 0.2591 1.32 0.1249 0.0379
Rbp1 retinol binding protein 1, cellular NM_011254 1.34 0.2364 -1.19 0.2941 1.00 0.9976 0.0101
Ephx1 epoxide hydrolase 1, microsomal; Eph1, Eph-1, AI195553 NM_010145 1.33 0.0486 -1.08 0.5597 1.05 0.8358 0.0181
Gsta4 Glutathione S-transferase, alpha 4 NM_010357 1.32 0.1312 -1.14 0.3506 -1.10 0.7389 0.0045
Ube2b ubiquitin conjugating enzyme, E2B (RAD 6 homoly S.cerevisea) NM_009458 -1.23 0.0358 -1.01 0.8808 1.00 0.9935 0.0350
Copeb core promoter element binding protein NM_011803 -1.21 0.8557 -1.28 0.1810 -1.44 0.1569 0.0471
Hao1 hydroxyacid oxidase NM_010403 -1.20 0.8890 1.12 0.5641 1.38 0.4200 0.0402
Anpep aminopeptidase N NM_008486 1.20 0.4022 -1.20 0.1456 -1.05 0.8153 0.0070
Egfr epidermal growth factor receptor NM_007912 -1.18 0.7714 -1.04 0.7719 1.21 0.4200 0.0429
Gpam glycerol-3-phosphate acyltransferase, mitochondrial NM_008149 -1.16 0.2258 -1.00 0.9864 1.13 0.4200 0.0068
Olfr1161 olfactory receptor 1161 NM_146848 1.13 0.8471 1.30 0.0420 1.27 0.1191 0.0300
Keap1 Kelch-like ECH-assoc. protein 1, cytosolic inhibitor of NRF2) NM_016679 -1.12 0.8821 -1.24 0.1165 -1.38 0.0941 0.0181
Ssrp1 Structure specific recognition protein 1 XM_130271 -1.10 0.8932 -1.13 0.3501 -1.34 0.1191 0.0121
mpg N-methylpurine-DNA glycosylase NM_010822 1.09 0.8894 1.30 0.0420 1.07 0.7269 0.0417
Ape2 AP endonuclease 2 NM_029943 -1.04 0.9530 -1.04 0.8232 -1.37 0.3673 0.0385
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 NM_009068 -1.03 0.9565 -1.10 0.5255 -1.43 0.1191 0.0490
Nme2 expressed in non-metastatic cells 2, protein NM_008705 1.02 0.9737 -1.24 0.2245 -1.12 0.7406 0.0238
Vegfb(2) vascular endothelial growth factor B NM_011697 -1.00 0.9944 -1.21 0.1279 -1.32 0.1191 0.0080
  1. * Data ordered by fold-change in 100 mg/ml dose. There were no significant genes in 0.1 mg/ml dose. Overall treatment effect