Table 1 ToxArray™ data normalized using EC: Overall adjusted p after exposure to PB and fold changes (relative to Control) and pairwise p-values at each dose for each gene (probe) that showed differential expression.
Control versus 100 mg/kg | Control versus 10 mg/kg | Control versus 1 mg/kg | James-Stein F-Test † | ||||||
|---|---|---|---|---|---|---|---|---|---|
Gene(probe) Name> | Full name | GenBank | Fold change | Pairwise P-value | Fold change | Pairwise P-value | Fold change | Pairwise P-value | Overall P-value |
Cyp2b9 | cytochrome P450, 2b9, phenobarbitol inducible, type a, | NM_010000 | 8.29 | 0.0000 | 3.22 | 0.0000 | 1.16 | 0.8087 | 0.0000 |
Cyp2b10 | Cytochrome P450, 2b10, phenobarbitol inducible, type b | NM_009998 | 5.10 | 0.0000 | 2.95 | 0.0000 | -1.08 | 0.8437 | 0.0000 |
Gdf15 | growth differentiation factor 15 | NM_011819 | 2.83 | 0.0000 | 1.25 | 0.3499 | 1.07 | 0.8667 | 0.0000 |
Gstm3 | glutathione S- transferase mu 3 (EC 2.5.1.18) | J03953 | 2.16 | 0.0000 | 1.04 | 0.8458 | 1.30 | 0.4200 | 0.0000 |
Lpin1 | lipin 1, alias fatty liver dystrophy | NM_015763 | -1.94 | 0.0009 | -1.18 | 0.3932 | -1.08 | 0.8437 | 0.0039 |
Gadd45b | growth arrest and DNA-damage-inducible 45 beta | NM_008655 | 1.92 | 0.0000 | 1.08 | 0.6595 | -1.13 | 0.7038 | 0.0000 |
Gadd45a | growth arrest and DNA damage inducible | NM_007836 | 1.66 | 0.0003 | 1.20 | 0.2245 | -1.24 | 0.4200 | 0.0000 |
Por | NADPH cytochrome p450 oxidoreductase | NM_008898 | 1.66 | 0.0806 | 1.22 | 0.3847 | 1.04 | 0.9392 | 0.0402 |
Tieg1 | TGFB inducible early growth response 1 | NM_013692 | -1.64 | 0.0011 | -1.23 | 0.1983 | -1.21 | 0.5440 | 0.0062 |
Gstm1 | glutathione S-transferase mu 1 | NM_010358 | 1.63 | 0.2258 | -1.14 | 0.6339 | -1.03 | 0.9622 | 0.0377 |
sult1c2 | sulfotransferase family 1C, member 2 | NM_026935 | 1.55 | 0.0044 | 1.16 | 0.3501 | 1.21 | 0.5440 | 0.0350 |
AhR | rat Ah receptor | NM_013464 | 1.48 | 0.0423 | -1.05 | 0.7919 | -1.12 | 0.7389 | 0.0039 |
Chk | choline kinase | NM_013490 | -1.45 | 0.0041 | -1.31 | 0.0876 | 1.02 | 0.9443 | 0.0039 |
Adcy6 | adenylate cyclase 6 | NM_007405 | -1.43 | 0.0003 | -1.20 | 0.1165 | -1.05 | 0.7925 | 0.0004 |
Bhmt | betaine homocysteine methyl transferase | NM_016668 | -1.40 | 0.2598 | -1.16 | 0.4362 | 1.19 | 0.6392 | 0.0385 |
gstm2 | glutathione S-transferase, mu 2 | NM_008183 | 1.39 | 0.0313 | -1.10 | 0.4647 | -1.01 | 0.9754 | 0.0054 |
Dusp6 | dual specificity phosphatase 6 | NM_026268 | 1.39 | 0.0852 | 1.23 | 0.2007 | -1.07 | 0.8288 | 0.0181 |
Lbp | Lipopolysaccharide binding protein | NM_008489 | 1.39 | 0.0104 | 1.15 | 0.2591 | 1.32 | 0.1249 | 0.0379 |
Rbp1 | retinol binding protein 1, cellular | NM_011254 | 1.34 | 0.2364 | -1.19 | 0.2941 | 1.00 | 0.9976 | 0.0101 |
Ephx1 | epoxide hydrolase 1, microsomal; Eph1, Eph-1, AI195553 | NM_010145 | 1.33 | 0.0486 | -1.08 | 0.5597 | 1.05 | 0.8358 | 0.0181 |
Gsta4 | Glutathione S-transferase, alpha 4 | NM_010357 | 1.32 | 0.1312 | -1.14 | 0.3506 | -1.10 | 0.7389 | 0.0045 |
Ube2b | ubiquitin conjugating enzyme, E2B (RAD 6 homoly S.cerevisea) | NM_009458 | -1.23 | 0.0358 | -1.01 | 0.8808 | 1.00 | 0.9935 | 0.0350 |
Copeb | core promoter element binding protein | NM_011803 | -1.21 | 0.8557 | -1.28 | 0.1810 | -1.44 | 0.1569 | 0.0471 |
Hao1 | hydroxyacid oxidase | NM_010403 | -1.20 | 0.8890 | 1.12 | 0.5641 | 1.38 | 0.4200 | 0.0402 |
Anpep | aminopeptidase N | NM_008486 | 1.20 | 0.4022 | -1.20 | 0.1456 | -1.05 | 0.8153 | 0.0070 |
Egfr | epidermal growth factor receptor | NM_007912 | -1.18 | 0.7714 | -1.04 | 0.7719 | 1.21 | 0.4200 | 0.0429 |
Gpam | glycerol-3-phosphate acyltransferase, mitochondrial | NM_008149 | -1.16 | 0.2258 | -1.00 | 0.9864 | 1.13 | 0.4200 | 0.0068 |
Olfr1161 | olfactory receptor 1161 | NM_146848 | 1.13 | 0.8471 | 1.30 | 0.0420 | 1.27 | 0.1191 | 0.0300 |
Keap1 | Kelch-like ECH-assoc. protein 1, cytosolic inhibitor of NRF2) | NM_016679 | -1.12 | 0.8821 | -1.24 | 0.1165 | -1.38 | 0.0941 | 0.0181 |
Ssrp1 | Structure specific recognition protein 1 | XM_130271 | -1.10 | 0.8932 | -1.13 | 0.3501 | -1.34 | 0.1191 | 0.0121 |
mpg | N-methylpurine-DNA glycosylase | NM_010822 | 1.09 | 0.8894 | 1.30 | 0.0420 | 1.07 | 0.7269 | 0.0417 |
Ape2 | AP endonuclease 2 | NM_029943 | -1.04 | 0.9530 | -1.04 | 0.8232 | -1.37 | 0.3673 | 0.0385 |
Ripk1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | NM_009068 | -1.03 | 0.9565 | -1.10 | 0.5255 | -1.43 | 0.1191 | 0.0490 |
Nme2 | expressed in non-metastatic cells 2, protein | NM_008705 | 1.02 | 0.9737 | -1.24 | 0.2245 | -1.12 | 0.7406 | 0.0238 |
Vegfb(2) | vascular endothelial growth factor B | NM_011697 | -1.00 | 0.9944 | -1.21 | 0.1279 | -1.32 | 0.1191 | 0.0080 |