Table 5 Measures of performance of microarray findings using normalization incorporating the external control features, compared to not incorporating the external control features.
A. Using all microarray pairwise comparisons | ||||
|---|---|---|---|---|
Microarray result using EC Normalization | Microarray result NOT using EC normalization | |||
RT-PCR result: | Significant | Not Significant | Significant | Not Significant |
Significant | 11 a | 3b | 8a | 9b |
Not Significant | 3c | 10d | 6c | 4d |
Sensitivity | 78.6% | 57.1% | ||
Specificity | 76.9% | 30.8% | ||
Positive Predictive Value | 78.6% | 47.1% | ||
Negative Predictive Value | 76.9% | 40.0% | ||
Efficiency of the test | 77.8% | 44.4% | ||
B. Using microarray pairwise comparisons that were in disagreement | ||||
Microarray result using EC Normalization | Microarray result NOT using EC normalization | |||
RT-PCR result: | Significant | Not Significant | Significant | Not Significant |
Significant | 5 a | 1b | 2a | 7b |
Not Significant | 3c | 10d | 6c | 4d |
Sensitivity | 62.5% | 25.0% | ||
Specificity | 90.9% | 36.4% | ||
Positive Predictive Value | 83.3% | 22.2% | ||
Negative Predictive Value | 76.9% | 40.0% | ||
Efficiency of the test | 79.0% | 31.6% | ||