Figure 1

Gene expressions and copy numbers in node negative and positive tumors. A, Expression ratios of 31 genes that differed in expression between 19 node negative and 29 node positive cervical tumors. The data are the average log₂ratio of two dye-swap experiments. Gene symbols (NCBI UniGene) are shown to the right. The genes indicated with a dark blue line were upregulated in node positive compared to node negative tumors, whereas those marked light blue were downregulated. The ratios were median centered, and expressions higher and lower than the median expression of that gene are shown in red and green, respectively. The most intense colors represent log₂ratios of > 2.0 (red) and < -2.0 (green) relative to the median, whereas black represents expression close to the median value. B, Gene copy number relative to modal DNA content (log₂ratio) of the BAC clones covering or are close to the genes in (A) for the patients presented in (A). Patient P-058 is not included, since tumor DNA was not available. BAC clone identifications and the corresponding gene symbols (NCBI UniGene) are shown to the right. Gene gains and losses are shown in red and green, respectively, whereas black represents no aberration. The most intense red and green colors represent log₂ratios of > 0.8 and < -0.8, respectively. The log₂ratios varied between -0.84 and 2.19.