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Figure 5 | BMC Genomics

Figure 5

From: Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer

Figure 5

Cluster analysis of genes and patients. A, Cluster diagram of MSN, TBX3, LSM3, CKS2, MRPL11, MRPS23, KLF3, and PDK2 expression in 19 node negative and 29 node positive cervical tumors. B, Cluster diagram of 48 cervical tumors based on MSN, TBX3, LSM3, CKS2, MRPL11, and MRPS23 expression (left) and Kaplan Meier plots of progression free survival for patients in group 1 and 4 (high expression of MRPL11, MRPS23, CKS2, and LSM3 and low expression of MSN and TBX3) versus group 2 and 3 (low expression of MRPL11, MRPS23, CKS2, and LSM3 and high expression of MSN and TBX3) (right). C, Cluster diagram of 48 cervical tumors based on KLF3 and PDK2 expression (left) and Kaplan Meier plots of progression free survival for patients in group 1 (high expression of KLF3 and low expression of PDK2) versus groups 2 (low expression of KLF3 and high expression of PDK2) (right). Clustering was performed based on the log2ratios, using absolute Pearson correlation (A) or Pearson correlation (B, C) algorithms. The ratios were median centered, and expressions higher and lower than the median expression of that gene are shown in red and green, respectively. The most intense colors represent log2ratios of > 1.0 (red) and < -1.0 (green) relative to the median value, whereas black represents expression close to median. Arrows point to patients with gain of MRPS23 and PDK2 (red) or loss of MSN (green). Group numbers and p-value in log rank test are indicated in the Kaplan Meier plots.

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