Table 1 Preference for codons at the beginning of HEG compared to all genes datasets. (H₀: there is no difference between codon frequencies in all genes and HEG).

E. coli

GCU

7.9E-06

15/3

ACU

1.1E-04

10/2

AUU

4.0E-05

16/4

AAA

0.001

15/5

GCA

6.0E-04

11/3

AAG

0.004

11/4

ACU

0.007

6/1

UCC

7.1E-04

8/1

B. subtilis

GCA

8.5E-05

15/3

GUA

0.004

9/2

GGA

0.002

9/2

-

H. pylori

GCA

0.001

15/4

-

-

AAG

0.009

9/2

ACA

0.005

6/1

H. influenzae

GCA

1.0E-04

17/4

GUA

0.005

6/1

GAA

0.009

11/4

-

GCU

0.002

11/3

UCU

0.006

10/3

M. tuberculosis

GCA

3.1E-04

11/2

AAG

2.9E-04

11/2

AAG

2.1E-04

11/2

AAG

8.5E-05

11/2

GCG

0.008

11/4

ACU

0.008

5/1

T. pallidum

GCA

6.9E-04

15/3

AAG

0.010

13/4

-

-

R. prowazekii

-

-

-

-

M. genitalium

-

-

-

-

B. burgdorferi

GCA

1.0E-04

15/2

-

-

-

UCA

9.9E-04

10/1

GGU

0.004

8/1

A. fulgidus

-

-

AAG

0.004

15/5

AAG

0.002

15/4

UAU

0.006

8/1

AGA

0.006

11/3

M. jannaschii

GCA

1.1E-05

14/2

GGA

0.003

9/2

-

-

GCU

0.002

9/2

CCA

0.008

7/1

P. horikoshii

-

-

AUG

0.004

27/12

-

S. cerevisiae

GCU

7.3E-08

19/3

AGA

2.5E-07

18/3

GUU

8.6E-08

15/2

AAG

8.4E-04

13/4

UCU

7.2E-07

24/6

CCA

0.006

6/1

GGU

0.002

8/2

ACU

0.001

11/3

GGU

1.0E-05

13/2

CCA

0.005

8/2

GUU

0.002

9/2

GCC

0.006

6/1

S. pombe

GCA

2.0E-07

22/4

CGU

4.5E-06

13/1

-

AAG

8.7E-04

13/3

GGA

0.002

8/1

AUU

0.001

13/3

AUC

0.009

7/1

P. falciparum

GGA

0.001

11/2

-

CAA

0.004

11/2

-

GCA

0.001

11/2

UCA

0.002

11/2

GCU

0.002

11/2

CCA

0.006

6/1