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Table 2 Ratio of G4 and C5 nucleotides between HEG and all genes datasets. For test of G4, genes with NCN codons and for test of C5, genes with GNN codons in the second position were removed from datasets. (H0: there is no difference between nucleotide frequencies in all genes and HEG).

From: Highly expressed proteins have an increased frequency of alanine in the second amino acid position

organism

G4

C5

 

P-value

HEG/all ratio

P-value

HEG/all ratio

E. coli

1.000

1.0

0.048

1.5

B. subtilis

0.490

0.7

0.111

1.7

H. pylori

0.644

1.2

0.004

2.6

H. influenzae

0.336

1.4

0.010

1.8

M. tuberculosis

0.010

0.0

0.495

1.2

T. pallidum

0.524

1.2

1.000

0.9

R. prowazekii

0.012

2.8

0.010

1.9

M. genitalium

0.298

1.3

0.763

1.2

B. burgdorferi

0.011

2.1

0.011

2.6

A. fulgidus

0.177

1.4

0.073

2.0

M. jannaschii

0.282

1.3

0.033

2.5

P. horikoshii

1.000

1.0

0.030

2.2

S. cerevisiae

0.006

1.8

2.8E-04

1.7

S. pombe

0.011

1.7

0.010

1.6

P. falciparum

0.004

2.1

1.3E-05

3.9