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Table 3 The six conserved domains used in this study to represent the RT sequence of RT-encoding MGEs.

From: An analysis of mobile genetic elements in three Plasmodium species and their potential impact on the nucleotide composition of the P. falciparum genome

RT region Domain Sequence
Fingers 1 II1XXL1[KG]S[GY]P1E1N[FP]K1XG1[RP][IV]XXI2,3[PL]K2,3[PK]D1[GK][GS]
Fingers 2 XR2,3P2[LI]2,3[TS]XXS3XXXK2,3IXQ1XV[IL]X[IK]XL2XXXXEXK
Palm A K1XXX[WS]X[TV]XL1D2,4I1K2K1,3CF2,3D2S2I2P1H2D1KL2I1XXL2XXY
Palm B' R1XXXXXXG2XP1Q2,3G2,3SX3XS2P2,3XL1F[NS]IYL1XXL2XE1XLXNXX
Palm C [YL]XR1Y2,3A1,3D2,4D2,4I[IL]V1X[VS]XXXKN
Palm D KXXLDXXTXFCXXIG2L1T1VN1XXK2T1K[IT]
  1. Alternative amino acid residues are in brackets. 'X' is any residue. 1 – residue present in three or more of the six aligned sequences; 2 – residue present in four or more of the six aligned sequences; 3 – residue in contact with nucleic acid template, dNTP or Mg2+ ; 4 – point mutations of this residue abolish catalytic activity.