Table 5 A short list of down regulated genes and supporting evidence for their involvement in AD
Item | Name | Acce # | Gene Description | Evidence for Down Regulation |
|---|---|---|---|---|
1 | APP | BC065529 | amyloid beta (A4) precursor protein | literature, [2], Down regulation in DS, [65] |
2 | CAST | NM_015576 | CAZ-associated structural protein | literature, [40] |
3 | CD59 | BC001506 | CD59 antigen p18-20 | literature, [66] |
4 | CDC10 | BX648365 | cell division cycle 10 | literature, [67] |
5 | HK1 | NM_033500 | hexokinase 1 | literature, [68] |
6 | PFKP | BC002536 | phosphofructokinase | literature, [37] |
7 | PTPN11 | NM_002834 | protein tyrosine phosphatase, non-receptor type 11 | literature, [69] |
8 | RPIP8 | BC013240 | RaP2interacting protein 8 | literature, [3] |
9 | SCD | NM_005063 | stearoyl-CoA desaturase | literature, [70] |
10 | SERPINE2 | NM_006216 | serine (or cysteine) proteinase inhibitor, clade E, member 2 | literature, [41] |
11 | UCHL1 | BC000332 | ubiquitin thiolesterase, UCHL1 | literature [71,72]. |
12 | SNCA | NM_000345 | synuclein, alpha | qRT-PCR, literature, [2] |
13 | A2M | BC040071 | alpha-2-macroglobulin | mutation of A2M is linked to AD, [16] |
14 | BRI3 | BC018737 | Brain protein I3 | mutation of BRI2 is liked to neurodegeneration[19] |
15 | EEF1A1 | BC009875 | Eukaryotic translation elongation factor 1 alpha 1 | mutation, mutant mice exhibit neurodegeneration, [14] |
16 | EIF2S2 | BC000461 | Eukaryotic translation initiation factor 2, subunit 2 beta | mutation, mutations causing childhood ataxia, [15] |
17 | MAPT | BC032572 | microtubule-associated protein tau, long splice form | mutation, mutation in exon 9–13 cause neurodegenerative diseases including AD, [18] |
18 | UBB | BC038999 | ubiquitin B | mutation, frame shift mutation fund in AD, [17] |
19 | ATP2B1 | AK024895 | ATPase, Ca++ transporting, plasma membrane 1 | inferred, expression is repressed by stress, [21] |
20 | CDK5R1 | BC035448 | cyclin-dependent kinase 5, regulatory subunit 1 | inferred, [73], and in ethanol induced neurodegeneration, [23] |
21 | CPLX1 | BC002471 | complexin 1 | inferred, Down regulated in schizophrenia, [24] |
22 | NES | AF086454 | nestin | inferred, decreased in injured aged hippocampus, [20] |
23 | RAD21 | NM_006265 | RAD21 homolog | inferred, Down regulated by hypoxia, [26] |
24 | ST13 | BC052982 | suppression of tumorigenicity 13 | inferred, rescue phosphorylated tau-induced cell death [25] |
25 | TAGLN3 | AF303058 | transgelin 3 | inferred, down regulated in schizophrenia, [22] |
26 | ARF6 | BC030291 | ADP-ribosylation factor 6 | qRT-PCR |
27 | BCAS1 | NM_003657 | Breast carcinoma amplified sequence 1 | qRT-PCR |
28 | CKIP-1 | BC010149 | CK2 interacting protein 1 | qRT-PCR |
29 | CRI1 | AL357456 | CREBP/EP300 inhibitory protein 1 | qRT-PCR |
30 | DEAF1 | BC053322 | deformed epidermal autoregulatory factor 1 | qRT-PCR |
31 | SCA1 | NM_000332 | spinocerebellar ataxia 1 | qRT-PCR |
32 | SV2A | BC045111 | synaptic vesicle glycoprotein 2A | qRT-PCR |
33 | TPI1 | BC017917 | triosephosphate isomerase | qRT-PCR |
34 | UBE2B | NM_003337 | ubiquitin-conjugating enzyme E2B | qRT-PCR |
35 | RELN | NM_005045 | reelin | qRT-PCR and inferred, down regulation or mutation cause autistic disorder, [27] |
36 | PRKCE | BC054052 | protein kinase C, epsilonY | qRT-PCR and inferred, suppresses Aβ production, [28] |
37 | SYT4 | BC036538 | synaptotagmin IV | qRT-PCR, inferred, SYT(unspecified isoform) is down regulated in CA1 of AD brains, [2] |