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Table 5 A short list of down regulated genes and supporting evidence for their involvement in AD

From: Novel subtractive transcription-based amplification of mRNA (STAR) method and its application in search of rare and differentially expressed genes in AD brains

Item Name Acce # Gene Description Evidence for Down Regulation
1 APP BC065529 amyloid beta (A4) precursor protein literature, [2], Down regulation in DS, [65]
2 CAST NM_015576 CAZ-associated structural protein literature, [40]
3 CD59 BC001506 CD59 antigen p18-20 literature, [66]
4 CDC10 BX648365 cell division cycle 10 literature, [67]
5 HK1 NM_033500 hexokinase 1 literature, [68]
6 PFKP BC002536 phosphofructokinase literature, [37]
7 PTPN11 NM_002834 protein tyrosine phosphatase, non-receptor type 11 literature, [69]
8 RPIP8 BC013240 RaP2interacting protein 8 literature, [3]
9 SCD NM_005063 stearoyl-CoA desaturase literature, [70]
10 SERPINE2 NM_006216 serine (or cysteine) proteinase inhibitor, clade E, member 2 literature, [41]
11 UCHL1 BC000332 ubiquitin thiolesterase, UCHL1 literature [71,72].
12 SNCA NM_000345 synuclein, alpha qRT-PCR, literature, [2]
13 A2M BC040071 alpha-2-macroglobulin mutation of A2M is linked to AD, [16]
14 BRI3 BC018737 Brain protein I3 mutation of BRI2 is liked to neurodegeneration[19]
15 EEF1A1 BC009875 Eukaryotic translation elongation factor 1 alpha 1 mutation, mutant mice exhibit neurodegeneration, [14]
16 EIF2S2 BC000461 Eukaryotic translation initiation factor 2, subunit 2 beta mutation, mutations causing childhood ataxia, [15]
17 MAPT BC032572 microtubule-associated protein tau, long splice form mutation, mutation in exon 9–13 cause neurodegenerative diseases including AD, [18]
18 UBB BC038999 ubiquitin B mutation, frame shift mutation fund in AD, [17]
19 ATP2B1 AK024895 ATPase, Ca++ transporting, plasma membrane 1 inferred, expression is repressed by stress, [21]
20 CDK5R1 BC035448 cyclin-dependent kinase 5, regulatory subunit 1 inferred, [73], and in ethanol induced neurodegeneration, [23]
21 CPLX1 BC002471 complexin 1 inferred, Down regulated in schizophrenia, [24]
22 NES AF086454 nestin inferred, decreased in injured aged hippocampus, [20]
23 RAD21 NM_006265 RAD21 homolog inferred, Down regulated by hypoxia, [26]
24 ST13 BC052982 suppression of tumorigenicity 13 inferred, rescue phosphorylated tau-induced cell death [25]
25 TAGLN3 AF303058 transgelin 3 inferred, down regulated in schizophrenia, [22]
26 ARF6 BC030291 ADP-ribosylation factor 6 qRT-PCR
27 BCAS1 NM_003657 Breast carcinoma amplified sequence 1 qRT-PCR
28 CKIP-1 BC010149 CK2 interacting protein 1 qRT-PCR
29 CRI1 AL357456 CREBP/EP300 inhibitory protein 1 qRT-PCR
30 DEAF1 BC053322 deformed epidermal autoregulatory factor 1 qRT-PCR
31 SCA1 NM_000332 spinocerebellar ataxia 1 qRT-PCR
32 SV2A BC045111 synaptic vesicle glycoprotein 2A qRT-PCR
33 TPI1 BC017917 triosephosphate isomerase qRT-PCR
34 UBE2B NM_003337 ubiquitin-conjugating enzyme E2B qRT-PCR
35 RELN NM_005045 reelin qRT-PCR and inferred, down regulation or mutation cause autistic disorder, [27]
36 PRKCE BC054052 protein kinase C, epsilonY qRT-PCR and inferred, suppresses Aβ production, [28]
37 SYT4 BC036538 synaptotagmin IV qRT-PCR, inferred, SYT(unspecified isoform) is down regulated in CA1 of AD brains, [2]
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BMC Genomics

ISSN: 1471-2164

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