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Table 6 A short list of up regulated genes and supporting evidence for their involvement in AD

From: Novel subtractive transcription-based amplification of mRNA (STAR) method and its application in search of rare and differentially expressed genes in AD brains

Item

Name

Acce #

Gene Description

Evidence for Down Regulation

1

CLU

NM_001831

clusterin

literature, [30,34]

2

GFAP

NM_002055

glial fibrillary acidic protein

literature, [29]

3

CP

NM_000096

ceruloplasmin

literature, [53]

4

DYRK1A

NM_001396

dual-specificity tyrosine-(Y) phosphorylationregulated kinase 1A

literature, [74]

5

FKBP1A

NM_000801

FK506 binding protein 1A

literature, [57]

6

FTL

BC058820

ferritin, light polypeptide

literature [3,34,52]

7

M6PR

NM_002355

mannose-6-phosphate receptor

literature, [75]

8

MAP2

NM_031846

microtubule-associated protein 2

literature, [3]

9

MBP

BC008749

myelin basic protein

literature, [49]

10

MT1F

NM_005949

metallothionein 1F

literature, [31]

11

RPL23

BC010114

ribosomal protein L23

literature, [3]

12

RPS27

NM_001030

ribosomal protein S27

literature, [76]

13

VDAC2

NM_003375

voltage-dependent anion channel 2

literature, [77]

14

YWHAE

BC001440

tyrosine 3-monooxygenase/tryptophan-5-monooxygenase activation protein, epsilon polypeptide

literature, [78]

15

AGT

NM_000029

angiotensinogen

literature, [34,79]

16

STXBP1

NM_003165

syntaxin binding protein 1

literature, [3,32], qRT-PCR did not show significant change

17

KNS2

BC008881

kinesin 2 60/70kDa

inferred, up regulated in injured optic nerve, [33], qRT-PCR did not show significant change

18

C21orf33

NM_004649

chromosome 21 open reading frame 33

inferred, elevated in fetal Down syndrome brain, [80]

19

FKBP2

NM_057092

FK506 binding protein 2

inferred, [57]

20

FREQ

NM_014286

frequenin homolog

inferred, up in Schizophrenia, [81]

21

GRM3

NM_000840

glutamate receptor, metabotropic 3

inferred, GRM2 and 4 increased in ischemic neurodegeneration, [82]

22

NPTX1

NM_002522

neuronal pentraxin I

inferred, short pentraxins are upregulated in AD, [50]

23

PDE8A

NM_002605

phosphodiesterase 8A

inferred, family member of PDE8B, is upregulated in AD, [83]

24

AHCTF1

AB059277

AT hook containing transcription factor 1

qRT-PCR

25

APRIN

NM_015032

androgen-induced proliferation inhibitor

qRT-PCR

26

CENTG2

NM_014914

centaurin, gamma 2

qRT-PCR

27

LMNA

NM_170708

lamin A/C

qRT-PCR

28

PLRG1

BC020786

pleiotropic regulator 1

qRT-PCR

29

PREPL

AB007896

prolyl endopeptidase-like

qRT-PCR

30

RPS20

NM_001023

ribosomal protein S20

qRT-PCR

31

SAFB

NM_002967

scaffold attachment factor B

qRT-PCR

32

SPTBN2

NM_006946

spectrin, beta, non-erythrocytic 2

qRT-PCR

33

SRGAP2

XM_059095

SLIT-ROBO Rho GTPase activating protein 2

qRT-PCR

34

USP10

NM_005153

ubiquitin specific protease 10

qRT-PCR

35

ARHGAP1

NM_004308

Rho GTPase activating protein 1 (CDC42GAP)

qRT-PCR, inferred, CDC42 is upregulated in AD, [60]

36

DRD1IP

NM_015722

dopamine receptor D1 interacting protein

qRT-PCR, inferred, up regulated in schizophrenia, [84]

37

MARK2

BC008771

MAP/microtubule affinity-regulating kinase 2

qRT-PCR, inferred, [85]

38

SCARB2

NM_005506

scavenger receptor class B, member 2, CD36 antigen

qRT-PCR, Inferred, inflammation increases CD36 mRNA, thus induceCD36 antigen, [51]

39

SEPT6

NM_015129

septin 6

qRT-PCR, inferred, increased in motor deficient mice,[86]

40

SKP1A

NM_170679

S-phase kinase-associated protein 1A

qRT-PCR, inferred, overexpression of SKP1A together with APP increase the production of Aβ, [87]