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Table 6 A short list of up regulated genes and supporting evidence for their involvement in AD

From: Novel subtractive transcription-based amplification of mRNA (STAR) method and its application in search of rare and differentially expressed genes in AD brains

Item Name Acce # Gene Description Evidence for Down Regulation
1 CLU NM_001831 clusterin literature, [30,34]
2 GFAP NM_002055 glial fibrillary acidic protein literature, [29]
3 CP NM_000096 ceruloplasmin literature, [53]
4 DYRK1A NM_001396 dual-specificity tyrosine-(Y) phosphorylationregulated kinase 1A literature, [74]
5 FKBP1A NM_000801 FK506 binding protein 1A literature, [57]
6 FTL BC058820 ferritin, light polypeptide literature [3,34,52]
7 M6PR NM_002355 mannose-6-phosphate receptor literature, [75]
8 MAP2 NM_031846 microtubule-associated protein 2 literature, [3]
9 MBP BC008749 myelin basic protein literature, [49]
10 MT1F NM_005949 metallothionein 1F literature, [31]
11 RPL23 BC010114 ribosomal protein L23 literature, [3]
12 RPS27 NM_001030 ribosomal protein S27 literature, [76]
13 VDAC2 NM_003375 voltage-dependent anion channel 2 literature, [77]
14 YWHAE BC001440 tyrosine 3-monooxygenase/tryptophan-5-monooxygenase activation protein, epsilon polypeptide literature, [78]
15 AGT NM_000029 angiotensinogen literature, [34,79]
16 STXBP1 NM_003165 syntaxin binding protein 1 literature, [3,32], qRT-PCR did not show significant change
17 KNS2 BC008881 kinesin 2 60/70kDa inferred, up regulated in injured optic nerve, [33], qRT-PCR did not show significant change
18 C21orf33 NM_004649 chromosome 21 open reading frame 33 inferred, elevated in fetal Down syndrome brain, [80]
19 FKBP2 NM_057092 FK506 binding protein 2 inferred, [57]
20 FREQ NM_014286 frequenin homolog inferred, up in Schizophrenia, [81]
21 GRM3 NM_000840 glutamate receptor, metabotropic 3 inferred, GRM2 and 4 increased in ischemic neurodegeneration, [82]
22 NPTX1 NM_002522 neuronal pentraxin I inferred, short pentraxins are upregulated in AD, [50]
23 PDE8A NM_002605 phosphodiesterase 8A inferred, family member of PDE8B, is upregulated in AD, [83]
24 AHCTF1 AB059277 AT hook containing transcription factor 1 qRT-PCR
25 APRIN NM_015032 androgen-induced proliferation inhibitor qRT-PCR
26 CENTG2 NM_014914 centaurin, gamma 2 qRT-PCR
27 LMNA NM_170708 lamin A/C qRT-PCR
28 PLRG1 BC020786 pleiotropic regulator 1 qRT-PCR
29 PREPL AB007896 prolyl endopeptidase-like qRT-PCR
30 RPS20 NM_001023 ribosomal protein S20 qRT-PCR
31 SAFB NM_002967 scaffold attachment factor B qRT-PCR
32 SPTBN2 NM_006946 spectrin, beta, non-erythrocytic 2 qRT-PCR
33 SRGAP2 XM_059095 SLIT-ROBO Rho GTPase activating protein 2 qRT-PCR
34 USP10 NM_005153 ubiquitin specific protease 10 qRT-PCR
35 ARHGAP1 NM_004308 Rho GTPase activating protein 1 (CDC42GAP) qRT-PCR, inferred, CDC42 is upregulated in AD, [60]
36 DRD1IP NM_015722 dopamine receptor D1 interacting protein qRT-PCR, inferred, up regulated in schizophrenia, [84]
37 MARK2 BC008771 MAP/microtubule affinity-regulating kinase 2 qRT-PCR, inferred, [85]
38 SCARB2 NM_005506 scavenger receptor class B, member 2, CD36 antigen qRT-PCR, Inferred, inflammation increases CD36 mRNA, thus induceCD36 antigen, [51]
39 SEPT6 NM_015129 septin 6 qRT-PCR, inferred, increased in motor deficient mice,[86]
40 SKP1A NM_170679 S-phase kinase-associated protein 1A qRT-PCR, inferred, overexpression of SKP1A together with APP increase the production of Aβ, [87]
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BMC Genomics

ISSN: 1471-2164

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