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Table 1 Characterization of cell lines used in training and validation

From: Gene expression patterns that predict sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer cell lines and human lung tumors

     

Affymetrix U133A chips

 
 

Cell Line

Type

Sensitivity to EGFR TKI

K-Ras Status

(n) in training

(n) in validation

EGFR Status

Training

A549

AC

No

Mutant (Codon 12)

8

N/A

Wt 1

 

UKY-29

AC

No

Mutant (Codon 61)1

3

N/A

Wt 1

 

H1650

AC

Yes

Wt

6

N/A

Mutant (DelE746-A750)1

 

PC-9

AC

Yes

Wt

5

N/A

Mutant (DelE746-A750)1

 

H3255

AC

Yes

Wt

3

N/A

Mutant (L858R) 1

Validation

H358

AC

Yes

Mutant (Codon 12)

0

1

Wt1

 

H460

Large Cell

No

Mutant (Codon 61)

0

1

Wt1

 

H1975

AC

No

Wt

0

1

Mutant (L858R, T790M) 1

 

K562

CML

No

Wt

0

1

Wt1

 

A431

Epidermoid

Yes

Wt

0

1

Wt (Amplified)1

  1. 1 Assayed in this study
  2. AC: Adenocarcinoma
  3. CML: Chronic Myelogenous Leukemia