Figure 3

Schematic diagram of structural features for USP17 subfamily members. The domains required for deubiquitinating activity (Cys, Asp (I) His, Asp/Asn (II)) are located at the 5' end and middle of enzymes. Two potential hyaluronan binding motifs R/K(X₇)R/K are located at amino acids 401 to 410, and 445 to 453.