The localization of USP17L and USP17N in HeLa cells. pEGFP-C1 vector (A) or pDsRed-C1 vector (B) transfected into HeLa cells was used as controls. In addition, GFP-tagged USP17L (C) or RFP-tagged USP17N (D) transfected into HeLa cells was used as controls. (E-G) HeLa cells co-transfected with GFP-tagged USP17L and RFP-tagged USP17N are shown with lower magnification (E-G) and with higher magnification (H-J). GFP-tagged USP17L proteins are highly condensed at the nucleoli in the nucleus (H: marked by arrows). RFP-tagged USP17N proteins are present both in the nucleus and cytoplasm (I: marked by arrows). GFP-tagged USP17L and RFP-tagged USP17N were combined in HeLa cells (G and J).