Skip to main content
Figure 6 | BMC Genomics

Figure 6

From: Simultaneous host and parasite expression profiling identifies tissue-specific transcriptional programs associated with susceptibility or resistance to experimental cerebral malaria

Figure 6

Gene groups previously implicated in host response to malaria with significant enrichment of genes selected by the linear model. The hypergeometric distribution was used to determine whether there was significant overlap between genes in categories previously implicated in malaria and those chosen by the linear model. Categories that showed an enrichment of differentially expressed genes included: A. Toll-like receptors, B. Immune response (cytokines, chemokines and their receptors), C. Interferon responsive genes, D. Acute phase proteins and E. Complement activation. Intensity values (median-subtracted, normalized, log2 scale) are shown for mouse genes (rows) represented on the microarray, in functional categories previously associated with malaria infection. Samples (columns) are chronologically ordered by organ. Left, heat maps showing relative intensity (%-tile Int.), and significance levels at day 0 (D0) or responding to infection (R.I.), which shows whether the corresponding gene was expressed significantly different between resistant and susceptible mice prior to infection, over infection or both. The final digits of its GO identifiers in parenthesis indicate GO-BP categories. Genes in each group were ordered using cosine-angle correlation and hierarchical clustering on the log-ratios.

Back to article page