Exploring glycopeptide-resistance in Staphylococcus aureus: a combined proteomics and transcriptomics approach for the identification of resistance-related markers

Table 4 List of significantly differentially expressed genes corresponding to over- or under-expressed proteins between 14-4 and 14-4Rev.

ORF number	Function	Transcript	Protein
SA0022	hypothetical protein, similar to 5'-nucleotidase	down	down
SA0591	hypothetical protein	up	up
SA0977	cell surface protein	down	down
SA1195	peptide methionine sulfoxide reductase regulator MsrR	up	up
SA1691	similar to penicillin-binding protein 1A/1B	up	up
SA2113	hypothetical protein	up	up

SA0591. Shows the VLTHEFGHVL motif, a characteristic of neutral Zn metallo-protease. Membrane associated protein.
SA2113. Shows partial homology with DNA repair protein from Psychrobacter arcticus and is particularly conserved among the different Staphylococcus aureus strains (often strictly identical nucleotide sequence).
SA0536.1. 1–19 N-terminal amino-acids are signal peptide (probably exported).

ISSN: 1471-2164