Figure 1

(a) Distribution of conservation score of proteins involved in cancer (red line) and all human proteins (blue line) against their closest homologue in M. musculus, R. norvegicus, G. gallus and between Paralogues. The conservation score gives an estimation of the mutation rate that the protein has been subjected to during evolution that is independent of the length of the protein. (b) Protein length, calculated as number of amino acids, and gene length distribution of cancer proteins (red) and all human proteins (blue).