Table 3 Selected GO annotations of genes involved in cancer compared to all human genes. The sign in the χ2 value indicates over-representation (positive values) or under-representation (negative values) of the GO term in the group of cancer proteins.
From: Structural and functional properties of genes involved in human cancer
GO id | GO term | #total | #cancer genes | χ2 |
|---|---|---|---|---|
GO:0045786 | negative regulation of cell cycle | 68 | 22 | 225.91 |
GO:0003684 | damaged DNA binding | 35 | 10 | 88.55 |
GO:0030528 | transcription regulator activity | 1034 | 76 | 85.86 |
GO:0006355 | regulation of transcription, DNA-dependent | 1281 | 84 | 73.49 |
GO:0003700 | transcription factor activity | 770 | 59 | 72.73 |
GO:0007049 | cell cycle | 601 | 48 | 64.36 |
GO:0005634 | nucleus | 2492 | 122 | 47.13 |
GO:0006366 | transcription from Pol II promoter | 181 | 19 | 41.93 |
GO:0008151 | cell growth and/or maintenance | 3014 | 137 | 40.58 |
GO:0003713 | transcription coactivator activity | 109 | 13 | 35.30 |
GO:0006281 | DNA repair | 94 | 11 | 28.98 |
GO:0003676 | nucleic acid binding | 2546 | 111 | 27.88 |
GO:0003824 | catalytic activity | 3768 | 62 | -14.46 |
GO:0006810 | transport | 1529 | 12 | -20.14 |
GO:0016021 | integral to membrane | 1986 | 20 | -20.31 |