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Table 5 GOstat results. Representation of different GO functional categories as determined by the GOstat program [48].

From: Genome-wide sequence and functional analysis of early replicating DNA in normal human fibroblasts

   Woodfine replication markers1
Function Islands > 1.75 1.75–1.5 < 1.5–1.25
Apoptosis (programmed cell death) over over   
Frizzled-2 (WNT) signaling pathway over    
Intracellular ligand-gated ion channel activity over    
Transmembrane receptor protein tyrosine kinase activity over    
Transmembrane receptor protein tyrosine phosphatase activity over    
G-protein coupled receptor activity under under   over
Rhodopsin-like receptor activity under under   over
G-protein coupled receptor protein signaling pathway under under under over
Olfactory receptor activity under   under over
Sensory perception of smell under   under over
Proteasome complex (sensu Eukaryota)   over   
Cation-transporting ATPase activity   over   
Positive regulation of signal transduction   over   
Lipid biosynthesis   over   
Lipid metabolism   over   
Intracellular protein transport   over   
Receptor signaling protein activity   over   
Regulation of transcription factor activity   over   
Protein binding2   over   under
Positive regulation of cellular process   over   under
Intracellular membrane-bound organelle   over   under
Cell surface receptor linked signal transduction   under under over
Transmembrane receptor activity   under   over
Neurophysiological process   under   over
Nucleosome assembly   under over  
DNA binding    over  
DNA metabolism    over  
Antigen processing endogenous antigen via MHC class I2    over  
MHC class I protein complex2    over  
MHC class I receptor activity2    over  
Calcium-mediated signaling    over  
Calcium ion binding    under  
Carbohydrate binding    under  
Muscle contraction    under  
Integral to membrane    under over
Phosphoric ester hydrolase activity     over
Organismal physiological process     over
Cell communication     over
Glutamate signaling pathway     over
Keratin filament     over
Sensory perception of taste     over
Positive regulation of cellular metabolism     under
  1. 1- Replication timing ratios determined by Woodfine et al. [18, 19].
  2. 2- Indicates functional categories overrepresented in genes associated with Woodfine et al. ([18, 19]) timing markers.