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Table 5 GOstat results. Representation of different GO functional categories as determined by the GOstat program [48].

From: Genome-wide sequence and functional analysis of early replicating DNA in normal human fibroblasts

  

Woodfine replication markers1

Function

Islands

> 1.75

1.75–1.5

< 1.5–1.25

Apoptosis (programmed cell death)

over

over

  

Frizzled-2 (WNT) signaling pathway

over

   

Intracellular ligand-gated ion channel activity

over

   

Transmembrane receptor protein tyrosine kinase activity

over

   

Transmembrane receptor protein tyrosine phosphatase activity

over

   

G-protein coupled receptor activity

under

under

 

over

Rhodopsin-like receptor activity

under

under

 

over

G-protein coupled receptor protein signaling pathway

under

under

under

over

Olfactory receptor activity

under

 

under

over

Sensory perception of smell

under

 

under

over

Proteasome complex (sensu Eukaryota)

 

over

  

Cation-transporting ATPase activity

 

over

  

Positive regulation of signal transduction

 

over

  

Lipid biosynthesis

 

over

  

Lipid metabolism

 

over

  

Intracellular protein transport

 

over

  

Receptor signaling protein activity

 

over

  

Regulation of transcription factor activity

 

over

  

Protein binding2

 

over

 

under

Positive regulation of cellular process

 

over

 

under

Intracellular membrane-bound organelle

 

over

 

under

Cell surface receptor linked signal transduction

 

under

under

over

Transmembrane receptor activity

 

under

 

over

Neurophysiological process

 

under

 

over

Nucleosome assembly

 

under

over

 

DNA binding

  

over

 

DNA metabolism

  

over

 

Antigen processing endogenous antigen via MHC class I2

  

over

 

MHC class I protein complex2

  

over

 

MHC class I receptor activity2

  

over

 

Calcium-mediated signaling

  

over

 

Calcium ion binding

  

under

 

Carbohydrate binding

  

under

 

Muscle contraction

  

under

 

Integral to membrane

  

under

over

Phosphoric ester hydrolase activity

   

over

Organismal physiological process

   

over

Cell communication

   

over

Glutamate signaling pathway

   

over

Keratin filament

   

over

Sensory perception of taste

   

over

Positive regulation of cellular metabolism

   

under

  1. 1- Replication timing ratios determined by Woodfine et al. [18, 19].
  2. 2- Indicates functional categories overrepresented in genes associated with Woodfine et al. ([18, 19]) timing markers.