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Figure 4 | BMC Genomics

Figure 4

From: Evolutionary anatomies of positions and types of disease-associated and neutral amino acid mutations in the human genome

Figure 4

Allele and genotype frequencies of non-synonymous SNPs at positions evolving with different evolutionary rates. (A) Relationship of the average minor allele frequencies of the nSNPs with the evolutionary rate (R2 = 0.85, P < 0.01) (blue). (B) The proportion of the nSNPs with a homozygous minor allele in at least one individual of the human population studied (blue). The rate index categories were merged into four bins, as mentioned in the Methods.

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