Figure 4

Allele and genotype frequencies of non-synonymous SNPs at positions evolving with different evolutionary rates. (A) Relationship of the average minor allele frequencies of the nSNPs with the evolutionary rate (R² = 0.85, P < 0.01) (blue). (B) The proportion of the nSNPs with a homozygous minor allele in at least one individual of the human population studied (blue). The rate index categories were merged into four bins, as mentioned in the Methods.