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Table 1 Frequency of disease-associated and non-synonymous (nSNPs) mutations in different evolutionary rate categories

From: Evolutionary anatomies of positions and types of disease-associated and neutral amino acid mutations in the human genome

Rate index (estimated rate range) Disease-associated genes (523) Other genes (2264)
  No. of positions DAMs No. of positions nSNPs
0 (0.000–0.125) 90,971 3,047 339,162 510
1 (0.126–0.250) 95,991 2958 546,466 622
2 (0.251–0.375) 39,751 649 203,711 688
3 (0.376–0.500) 41,570 618 208,192 588
4 (0.501–0.625) 18,235 240 96,819 343
5 (0.626–0.750) 21,490 227 108,584 571
6 (0.751–0.875) 16,061 145 72,280 395
7 (0.876–1.000) 11,451 82 44,487 305
Total 335,520 7,966 1,619,701 4,022
  1. NOTE: – The evolutionary rates of amino acid positions obtained from Maximum Likelihood analysis ranges from 0.32 to 3.4. For simplicity, we normalized each rate value by dividing by 3.4 in order to make the scale from 0.094–1.000. The amino acid positions were then grouped into eight categories based on their relative rate of evolution with an interval of 0.125.