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Table 3 The biochemical severity of disease-associated mutations, differences among species, and nonsynonymous mutations

From: Evolutionary anatomies of positions and types of disease-associated and neutral amino acid mutations in the human genome

Type Number of observations Grantham Distance
   Average Std. Error
Disease-associated 7,966 92.06 0.57
Nonsynonymous SNPs 4,022 64.95 0.65
Differences among species 148,558 66.61 0.19
  1. 1 -Grantham measure [19] was used to quantify the biochemical distance between amino acids.