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Table 3 The biochemical severity of disease-associated mutations, differences among species, and nonsynonymous mutations

From: Evolutionary anatomies of positions and types of disease-associated and neutral amino acid mutations in the human genome

Type

Number of observations

Grantham Distance

  

Average

Std. Error

Disease-associated

7,966

92.06

0.57

Nonsynonymous SNPs

4,022

64.95

0.65

Differences among species

148,558

66.61

0.19

  1. 1 -Grantham measure [19] was used to quantify the biochemical distance between amino acids.