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Table 2 Cross-species comparison of gene essentiality between human and S. cerevisiae.

From: Further understanding human disease genes by comparing with housekeeping genes and other genes

  Total Essential Non-essential Unknown
Homologs of UEHGs 384 (20.2% of UEHGs)* 138 (35.9%) (7.3% of UEHGs)* 242(63.0%) 4(1.1%)
Homologs of disease genes 196 (9.8% of disease genes)* 51 (26.0%) (2.5% of disease genes)* 142(72.5%) 3(1.5%)
Homologs of other genes 1005 (3.5% of other genes)* 379 (37.7%) (1.3% of other genes)* 618(61.5%) 8(0.8%)
No homologs 4641 505 (10.9%) 3427(73.8%) 709(15.3%)
Total yeast genes 6179 1058 (17.1%) 4397(71.2%) 724(11.7%)
  1. Yeast genes are mapped to three human gene groups by homologous mapping. The first three rows are for each human gene group and the fourth row is for yeast genes without human homologous genes. The last row summarizes all the yeast genes. The first column lists the number of homologous genes found for each human gene group and the fractions with respect to the number of human genes in the corresponding group (show in brackets marked with *). The following columns list the number of yeast essential, non-essential, and unknown genes for each human gene group. The fractions with respect to the number of homologs found in each group are shown in brackets. In the second column, the fraction of homologous essential genes over the human genes in each group is given in the bracket with *.