Table 3 Elevated expression of ORFs associated with single- and double-strand damage caused by exposure of S. cerevisiae to γ-radiation and enediynesa
From: The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA
Elevated Expression of ORFS Associated with Single-Strand Damage | Elevated Expression of ORFS Associated with Double-Strand Damage | ||||
|---|---|---|---|---|---|
ORF | Gene Name | Description | ORF | Gene Name | Description |
YLR164W | --- | YLR164Wp is homologous to TIM18p | YNL300W | --- | Hypothetical ORF |
YPR015C | --- | Hypothetical ORF | YGL101W | --- | Hypothetical ORF |
YHL035C | --- | ABC transporter | YLR054C | --- | Non-essential protein required for construction of the outer spore wall layers |
YLR326W | --- | Hypothetical ORF | YLR290C | --- | Hypothetical ORF |
YDL152W | --- | --- | YER185W | --- | Hypothetical ORF |
YIR036C | --- | Hypothetical ORF | YNL141W | AAH1 | adenine aminohydrolase (adenine deaminase) |
YCL033C | --- | Hypothetical ORF | YBR158W | AMN1 | Involved in daughter cell separation and Chromosome STability |
YLR077W | --- | The authentic, non-tagged protein was localized to the mitochondria | YHR208W | BAT1 | branched-chain amino acid transaminase |
YBR070C* | --- | Protein required for cell viability | YHR052W | CIC1 | Core interacting component 1 |
YLR109W | AHP1 | alkyl hydroperoxide reductase | YPL256C | CLN2 | G1 cyclin |
YJL115W | ASF1 | anti-silencing protein | YNL112W | DBP2 | ATP dependent RNA helicase|dead box protein |
YML102W | CAC2 | chromatin assembly factor-I (CAF-I) p60 subunit | YDL160C | DHH1 | Cytoplasmic DExD/H-box helicase |
YOR031W | CRS5 | metallothionein-like protein | YJL157C | FAR1 | Cdc28p kinase inhibitor |
YDL101C* | DUN1 | protein kinase | YIL131C | FKH1 | forkhead protein |
YDL018C | ERP3 | p24 protein involved in membrane trafficking | YBR010W | HHT2 | histone H3 (HHT1 and HHT2 code for identical proteins) |
YIR038C | GTT1 | glutathione transferase | YER110C | KAP123 | karyopherin beta 4 |
YBR072W | HSP26 | heat shock protein 26 | YOL025W | LAG2 | affects longevity |
YIR037W | HYR1 | glutathione-peroxidase (putative) | YDR234W | LYS4 | homoaconitase |
YOR328W | PDR10 | ABC transporter (putative)|highly similar to Pdr5p | YIL106W | MOB1 | Mps One Binder |
YNL102W | POL1 | DNA polymerase I alpha subunit p180 | YDR033W | MRH1 | Protein that localizes primarily to the plasma membrane |
YER095W* | RAD51 | Rad51p colocalizes to ~65 spots with Dmc1p prior to synapsis | YBR093C | PHO5 | acid phosphatase |
YNL312W | RFA2 | 29% identical to the human p34 subunit of RF-A|replication factor RF-A subunit 2 | YGL028C | SCW11 | glucanase |
YJL026W* | RNR2 | ribonucleotide reductase subunit | YGR245C | SDA1 | Severe Depolymerization of Actin |
YGL103W | RPL28 | ribosomal protein L28 (L29) (rp44) (YL24) | YIL162W | SUC2 | invertase (sucrose hydrolyzing enzyme) |
YGR027C | RPS25A | ribosomal protein S25A (S31A) (rp45) (YS23) | YDR297W | SUR2 | sphingosine hydroxylase |
YER096W | SHC1 | Sporulation-specific activator | YPR016C | TIF6 | similar to human translation initiation factor 6 (eIF6); |
YDR120C | TRM1 | N2,N2-dimethylguanosine-specific tRNA methyltransferase | |||
YBL004W | UTP20 | U3 snoRNP protein | |||
YBR104W | YMC2 | Putative mitochondrial inner membrane transporter | |||