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Table 3 Elevated expression of ORFs associated with single- and double-strand damage caused by exposure of S. cerevisiae to γ-radiation and enediynesa

From: The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA

Elevated Expression of ORFS Associated with Single-Strand Damage Elevated Expression of ORFS Associated with Double-Strand Damage
ORF Gene Name Description ORF Gene Name Description
YLR164W --- YLR164Wp is homologous to TIM18p YNL300W --- Hypothetical ORF
YPR015C --- Hypothetical ORF YGL101W --- Hypothetical ORF
YHL035C --- ABC transporter YLR054C --- Non-essential protein required for construction of the outer spore wall layers
YLR326W --- Hypothetical ORF YLR290C --- Hypothetical ORF
YDL152W --- --- YER185W --- Hypothetical ORF
YIR036C --- Hypothetical ORF YNL141W AAH1 adenine aminohydrolase (adenine deaminase)
YCL033C --- Hypothetical ORF YBR158W AMN1 Involved in daughter cell separation and Chromosome STability
YLR077W --- The authentic, non-tagged protein was localized to the mitochondria YHR208W BAT1 branched-chain amino acid transaminase
YBR070C* --- Protein required for cell viability YHR052W CIC1 Core interacting component 1
YLR109W AHP1 alkyl hydroperoxide reductase YPL256C CLN2 G1 cyclin
YJL115W ASF1 anti-silencing protein YNL112W DBP2 ATP dependent RNA helicase|dead box protein
YML102W CAC2 chromatin assembly factor-I (CAF-I) p60 subunit YDL160C DHH1 Cytoplasmic DExD/H-box helicase
YOR031W CRS5 metallothionein-like protein YJL157C FAR1 Cdc28p kinase inhibitor
YDL101C* DUN1 protein kinase YIL131C FKH1 forkhead protein
YDL018C ERP3 p24 protein involved in membrane trafficking YBR010W HHT2 histone H3 (HHT1 and HHT2 code for identical proteins)
YIR038C GTT1 glutathione transferase YER110C KAP123 karyopherin beta 4
YBR072W HSP26 heat shock protein 26 YOL025W LAG2 affects longevity
YIR037W HYR1 glutathione-peroxidase (putative) YDR234W LYS4 homoaconitase
YOR328W PDR10 ABC transporter (putative)|highly similar to Pdr5p YIL106W MOB1 Mps One Binder
YNL102W POL1 DNA polymerase I alpha subunit p180 YDR033W MRH1 Protein that localizes primarily to the plasma membrane
YER095W* RAD51 Rad51p colocalizes to ~65 spots with Dmc1p prior to synapsis YBR093C PHO5 acid phosphatase
YNL312W RFA2 29% identical to the human p34 subunit of RF-A|replication factor RF-A subunit 2 YGL028C SCW11 glucanase
YJL026W* RNR2 ribonucleotide reductase subunit YGR245C SDA1 Severe Depolymerization of Actin
YGL103W RPL28 ribosomal protein L28 (L29) (rp44) (YL24) YIL162W SUC2 invertase (sucrose hydrolyzing enzyme)
YGR027C RPS25A ribosomal protein S25A (S31A) (rp45) (YS23) YDR297W SUR2 sphingosine hydroxylase
YER096W SHC1 Sporulation-specific activator YPR016C TIF6 similar to human translation initiation factor 6 (eIF6);
    YDR120C TRM1 N2,N2-dimethylguanosine-specific tRNA methyltransferase
    YBL004W UTP20 U3 snoRNP protein
    YBR104W YMC2 Putative mitochondrial inner membrane transporter
  1. a WT S. cerevisiae was exposed to enediynes or γ-radiation and regression analysis identified genes with increased transcriptional activation associated either with single-strand (left) or double-strand damage (right). Members of the DNA damage signature are highlighted in grey and denoted with an asterisk (*).