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Table 4 Three-field EC number validation of enzyme functions predicted by EFICAz with three-field EC numbers for 27 previously hypothetical proteins

From: High precision multi-genome scale reannotation of enzyme function by EFICAz

Domain

Org.1

Gene name2

PMID3

True EC number4

Predicted EC number5

EC field Agreement6

Archaea

afu

AF1938

11790732

6.2.1.1

6.2.1.-

3

Bacteria

bsu

BG11467

14635137

2.3.1.-

2.3.1.-

3

Bacteria

bsu

BG11761

16242712

1.1.1.-

1.1.1.-

3

Bacteria

bth

BT4131

15952775

3.1.3.-

3.1.3.-

3

Bacteria

ecc

c1394

15157072

2.7.1.-

2.7.1.-

3

Bacteria

ecc

c2089

16253988

2.8.3.-

2.8.3.-

3

Bacteria

eco

b2873

11092864

3.5.2.-

3.5.2.-

3

Bacteria

cef

CE0356

15225990

2.3.1.-

2.3.1.-

3

Bacteria

lpf

lpl2377

16390437

2.7.3.-

2.7.3.-

3

Bacteria

lpp

lpp2524

16390437

2.7.3.-

2.7.3.-

3

Bacteria

lpp

lpp2599

11053398

2.1.1.-

2.1.1.-

3

Archaea

mja

MJ0883

15165845

2.1.1.31

2.1.1.-

3

Archaea

pho

PH1035

15737605

2.4.1.-

2.4.1.-

3

Archaea

pho

PH1915

16260766

2.1.1.-

2.1.1.-

3

Archaea

pho

PH1948

16245322

2.1.1.-

2.1.1.-

3

Bacteria

rpr

RP028

16364512

2.1.1.43

2.1.1.-

3

Bacteria

mtu

Rv0891c

15500449

4.6.1.1

4.6.1.-

3

Bacteria

mtu

Rv1500

16257960

2.4.1.-

2.4.1.-

3

Bacteria

mtu

Rv3225c

12715873

2.7.1.-

2.7.1.-

3

Bacteria

sco

SCO2599

12951512

3.1.4.-

3.1.4.-

3

Bacteria

spn

SP1051

12571357

2.7.1.-

2.7.1.-

3

Archaea

sto

ST0071

15212797

3.1.1.-

3.1.1.-

3

Archaea

sto

ST0723

16618099

1.5.1.30

1.5.1.-

3

Bacteria

ttj

TTHA1280

16511182

2.1.1.-

2.1.1.-

3

Bacteria

ypk

y0368

12923112

2.3.1.-

2.3.1.-

3

Bacteria

ype

YPO3632

16452420

2.3.1.-

2.3.1.-

3

Archaea

tac

Ta1419

14551194

5.3.1.8 5.3.1.9

6.1.1.-

0

  1. 1 The species names corresponding to the KEGG three letter codes are listed in the footnote of Table 1.
  2. 2 Gene name from the Genes database of KEGG.
  3. 3 PMID: PubMed Unique Identifier, the journal citation accession number for the most relevant record in PubMed supporting the experimentally-derived annotation [65].
  4. 4 Experimentally-derived EC numbers.
  5. 5 EFICAz-predicted EC numbers.
  6. 6 Number of matching first n fields of the experimentally-derived and EFICAz-predicted EC numbers, with n = 1 to 4.