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Table 4 Frequency decrease of G:C→A:T after removal of CpG→TpG/CpA SNPs

From: Directionality of point mutation and 5-methylcytosine deamination rates in the chimpanzee genome

Category

GC content (%)

Frequency decrease of G:C→A:T (%)

  

Un-normalized

Normalized

Genome

40.0

8.8

9.7

Intergenic regions

39.4

8.2

9.2

Genes

41.0

9.7

10.4

Introns

39.7

8.8

9.7

Exons

51.7

19.4

19.2

CpG islands

62.0

12.1

11.2

Intergenic regions

<35 (31.4a)

5.7

7.1

 

35–40 (37.3)

7.2

8.1

 

40–45 (42.2)

9.0

9.6

 

45–50 (47.2)

11.1

11.3

 

50–55 (52.2)

13.0

12.8

 

55–60 (57.2)

15.3

14.9

 

≥ 60 (63.9)

18.2

17.4

 

55–75 (60.2) b

16.6

16.0

  1. aThe average GC content (%) in the subcategory of intergenic regions.
  2. bThis GC content bin was included for the comparison with the CpG island category.