A Three-dimensional plot of the FOREL clusters from Mootha et al. data set in relationship to Body Mass Index (BMI), total oxygen capacity (VO2max) and insulin sensitivity (M-value). Members of cluster 3, occupying the extreme end of the variation spectrum and two singletons (both non-diabetic) are the most insulin sensitive. Some non-diabetic phenotypes are found in clusters characterized by high risk factors (↓M-value, ↑BMI) particularly cluster 4. Conversely, there is only one subject with IGT in cluster 3. On this plot clusters are represented by corresponding centroids.