Expression of secretion stress related genes of S. cerevisiae under different stress conditions. Expression values of the genes (shown as log2 of the expression level ratio in stress vs. reference conditions) from 174 different stress conditions were collected from published articles. The expression level values of individual genes are shown in purple or green and the median of the gene group in black and the standard deviation of the whole experiment in blue. A: "c oreUPR", genes showing significant up regulation in "Treated WT" experiment set against both the "Treated ρ" and "REF" experiment sets. B: "Travers UPR", genes defined as UPR genes and genes defined as UPR model genes in yellow by . C: "UPR Dependent Up", genes showing significant up regulation only in "Treated WT" set against "Treated ρ" set. D: "UPR Dependent Down", genes showing significant down regulation only in "Treated WT" against "Treated ρ" set. E: "UPR Independent Up", genes showing significant up regulation only in "Treated WT" against "REF" set. F: "UPR Independent Down", genes showing significant down regulation only in "Treated WT" against "REF" set. The stress conditions were divided in sets as follows: Treated ρ IRE1 and HAC1 deletion strains treated with DTT or tunicamycin, used as UPR dependent reference set in this study [2, 3]; REF reference set, used as UPR independent reference in this study [17, 18]; Treated WT cultures treated with DTT or tunicamycin or recombinant strains producing a secreted heterologous protein, used as UPR conditions in this study [2, 3, 17-19, 69]; DTT DTT treatment, 4 h time series ; Cd2+ stress Cd2+ treatment, 2 h time series and met4 deletion ; ρCell Wall strains deleted in cell wall genes ; AA-depl. methyl methanesulfonate, 3-aminotriazole and amino acid depletion treatments and GCN4 constitutive and GCN4 deletion strains ; Heat Shock 1 h time series after heat shock from 25°C to 37°C, ; 37 to 25 1, 5 h time series after temperature shift from 37°C to 25°C, ; 29C to 33C 1, 5 h time series after mild heat shock of 29°C to 33°C ; Sorbi. & Heat S. mild heat shock with different osmolarities, like previous but with sorbitol treatments ; Heat Shocks different heat shocks ; H202 2 h time series after hydrogen peroxide treatment ; Menadione 2 h time series after menadione treatment ; Diamide 1, 5 h time series after diamide treatment ; Sorbitol 2 h time series after hyper-osmotic shock with sorbitol ; Hypo-o shock 1 h time series after hypo-osmotic shock with sorbitol ; Ade. depl. 6 h time series after amino acid and adenine depletion ; N depl. 3 d time series after nitrogen depletion ; YPD 25C 13 d 13 d time series of growth on YPD at 25°C ; YPD 30C 5 d 5 d time series of growth on YPD at 30°C ; Other other conditions .