Table 1 Representation of different function and location categories of genes in the different groups of secretion stress related genes of S. cerevisiae. Number of S. cerevisiae genes belonging to selected function and location categories within the different groups of secretion stress related genes distinguished in this article. The groups of differentially regulated genes: "c oreUPR", "UPR Dependent Up "UPR Dependent Down", UPR Independent Up" and "UPR Independent Down", are defined in Materials and methods of this study and "UPR by Travers & al. 2000" (UPR regulated genes) are as described by [2], and "Homologues of T. reesei secretion stress ORFs" (numbers of ORFs corresponding to ESTs represented in the cDNA subtraction library and cDNA-AFLP analysis in this study). Category assignments are from CYGD functional or localization categories [51].
| Topic | Category | cUPR | UPR Dependent UP | UPR Dependent DOWN | Not UPR Dependent UP | Not UPR Dependent DOWN | UPR by Travers & al. 2000 | Homologues of T. reesei ER stress ORFs | S. cerevisiae genome |
|---|---|---|---|---|---|---|---|---|---|
| Protein secretion related | Cellular export and secretion | 2 | 11 | 3 | 3 | 7 | 76 | ||
| Protein fate | 23 | 30 | 25 | 137 | 65 | 95 | 62 | 1130 | |
| Lipid, fattyacid and isoprenoid metabolism | 6 | 10 | 5 | 33 | 18 | 28 | 16 | 271 | |
| Vacuolar transport | 2 | 2 | 4 | 26 | 9 | 10 | 11 | 152 | |
| Vesicular transport | 8 | 5 | 3 | 23 | 7 | 27 | 20 | 197 | |
| Biogenesis of cellular componentsCell wall | 2 | 8 | 4 | 21 | 11 | 21 | 16 | 212 | |
| % of Protein secretion related genes in the group | 63% | 31% | 20% | 34% | 16% | 38% | 39% | 26% | |
| Transcription related | Transcriptional control | 1 | 23 | 8 | 44 | 33 | 26 | 23 | 491 |
| Transcription | 3 | 35 | 19 | 69 | 140 | 48 | 31 | 1060 | |
| % of Transcription related genes in the group | 7% | 26% | 13% | 12% | 23% | 13% | 14% | 17% | |
| Outside of cell | Extracellular | 1 | 2 | 9 | 5 | 5 | 50 | ||
| Cellwall | 2 | 5 | 1 | 3 | 40 | ||||
| % of genes Outside of cell in the group | 0% | 0% | 1% | 1% | 2% | 1% | 2% | 1% | |
| Ribosome biogenesis | 2 | 3 | 130 | 3 | 20 | 301 | |||
| Histones | 3 | 8 | |||||||
| % of Unclassifed genes in the group | 20% | 21% | 40% | 27% | 17% | 27% | 9% | 32% | |
| Total number of genes in the group | 46 | 135 | 155 | 592 | 603 | 381 | 249 | 6335 | |