Changes in skeletal muscle gene expression following clenbuterol administration

BMC Genomics

Table 5 Evaluation of differentially expressed genes of interest (P < 0.01) to identify over-represented families of genes^a.

Gene Ontology Biological Process Category^b	List Hits^c	Population Hits^d	EASE Score^e
Homeostasis (Cell homeostasis, Cation homeostasis, Cell ion homeostasis, Ion homeostasis)	10	63	.002
Amino acid and derivative metabolism (Amine metabolism, Amino acid metabolism)	16	196	.010
Intracellular signalling cascade	34	519	.021
Neurogenesis	17	209	.023
Transcription from Pol II promoter (Positive regulation of transcription)	18	229	.025
Translation (Translational initiation)	13	144	.025
Physiological processes	281	6030	.030
Morphogenesis	38	617	.034
Lymphocyte activation	6	42	.036
Protein-mitochondrial targeting	3	8	.046

^aData were evaluated using EASE software [66] and Gene Ontology biological process categories.
^bCategories with evidence for over-representation (EASE score < 0.05) are shown, with redundant categories listed in parentheses.
^cThe number of genes from the list of differentially expressed genes within each over-represented category. A total of 331 differentially expressed genes were assigned to a category.
^dThe number of genes included on the MOE430A and B chips within each over-represented category. A total of 7,464 genes were assigned to a category.
^eThe EASE score is the upper bound of the distribution of Jackknife Fisher exact probabilities.

ISSN: 1471-2164