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Table 2 Feature indices of RP genes.

From: Characteristics and clustering of human ribosomal protein genes

RP gene

Expression profile cluster

Amino acid encording cluster

Synonymous codon frequency cluster

TATA box (-40 bp ~ -21 bp)

Predicted Transcription factors bound

Feature Index

RPLP0

S2

O

M

Y

AP

3.3

RPS26

O

O

M

Y

GC, AP

3.2

RPSA

M

O

S2

N

AP

2.3

RPS29

M

S2

O

N

AP

2.3

RPL5

M

M

S1

N

AP

2.3

RPL14

M

O

S2

N

GC

2.3

RPLP1

S1

S1

M

N

NRF, AP

2.2

RPLP2

S1

S1

M

N

NRF, GC

2.2

RPL36A

M

S2

M

Y

NRF, AP

2.2

RPS6

-

M

S1

N

NRF, GC, AP

2.1

RPS18

S2

M

M

Y

NRF, GC, AP

2.1

RPS27

M

O

M

Y

GC, YY, AP

2.1

RPL28

O

M

O

N

NRF, GC, AP

2.1

RPL41

-

O

O

N

NRF, GC, AP

2.1

RPS3A

M

M

S1

N

NRF, GC, YY, AP

2.0

RPS4Y

O

M

S1

N

-

2.0

RPS28

-

O

M

Y

NRF, GC, YY, AP

2.0

RPL4

M

M

S1

N

NRF, GC, YY, AP

2.0

RPL39

M

S2

O

N

NRF, GC, YY, AP

2.0

RPS15A

S2

M

M

N

YY

1.3

RPS23

M

M

S2

N

GC

1.3

RPS24

O

M

M

N

NRF

1.3

RPL6

O

M

M

N

NRF

1.3

RPL7

M

M

S2

N

AP

1.3

RPL9

-

M

S2

N

AP

1.3

RPL37A

M

S2

M

N

NRF

1.3

RPS15

M

M

O

N

NRF, AP

1.2

RPS21

-

O

M

N

GC, AP

1.2

RPL31

O

M

M

N

NRF, GC

1.2

RPL32

O

M

M

N

NRF, AP

1.2

RPL35

O

M

M

N

GC, AP

1.2

RPL37

-

S2

M

N

NRF, AP

1.2

RPS2

O

M

M

N

NRF, GC, AP

1.1

RPS3

M

O

M

N

NRF, YY, AP

1.1

RPS5

-

O

M

N

NRF, GC, AP

1.1

RPS12

-

O

M

N

GC, YY, AP

1.1

RPS17

O

M

M

N

NRF, GC, AP

1.1

RPS25

-

M

S2

N

NRF, GC, AP

1.1

RPL3

M

M

O

N

NRF, GC, YY

1.1

RPL17

M

M

S2

N

NRF, YY, AP

1.1

RPL21

M

M

S2

N

GC, YY, AP

1.1

RPL29

S2

M

M

N

NRF, GC, AP

1.1

RPS13

M

M

S2

N

NRF, GC, YY, AP

1.0

RPS27A

M

M

S2

N

NRF, GC, YY, AP

1.0

RPL10

-

M

M

Y

NRF, GC, YY, AP

1.0

RPL27A

O

M

M

N

NRF, GC, YY, AP

1.0

RPS9

-

M

M

N

AP

0.3

RPS11

M

M

M

N

YY

0.3

RPL7A

M

M

M

N

GC

0.3

RPL13

M

M

M

N

NRF

0.3

RPL13A

M

M

M

N

YY

0.3

RPL22

M

M

M

N

GC

0.3

RPL34

-

M

M

N

NRF

0.3

RPS7

M

M

M

N

GC, AP

0.2

RPS10

-

M

M

N

NRF, GC

0.2

RPS20

M

M

M

N

GC, AP

0.2

RPS30

M

M

M

N

GC, AP

0.2

RPL8

M

M

M

N

NRF, AP

0.2

RPL10A

M

M

M

N

NRF, GC

0.2

RPL11

M

M

M

N

NRF, GC

0.2

RPL12

-

M

M

N

GC, AP

0.2

RPL18

M

M

M

N

GC, AP

0.2

RPL23A

M

M

M

N

GC, YY

0.2

RPL26

M

M

M

N

NRF, AP

0.2

RPL35A

-

M

M

N

GC, AP

0.2

RPS4X

M

M

M

N

NRF, GC, AP

0.1

RPS8

M

M

M

N

GC, YY, AP

0.1

RPS16

M

M

M

N

NRF, GC, AP

0.1

RPS19

M

M

M

N

NRF, GC, AP

0.1

RPL15

M

M

M

N

GC, YY, AP

0.1

RPL18A

-

M

M

N

NRF, YY, GC

0.1

RPL19

M

M

M

N

NRF, GC, AP

0.1

RPL23

M

M

M

N

NRF, GC, AP

0.1

RPL24

M

M

M

N

NRF, YY, GC

0.1

RPL27

-

M

M

N

NRF, GC, AP

0.1

RPL30

M

M

M

N

NRF, YY, AP

0.1

RPL36

-

M

M

N

NRF, YY, AP

0.1

RPL38

M

M

M

N

NRF, GC, AP

0.1

RPL40

M

M

M

N

GC, YY, AP

0.1

RPS14

-

M

M

N

NRF, GC, YY, AP

0.0

  1. The feature index (FI) is a quantitative measure of the heterogeneity in an individual RP gene. Expression profile, amino acids encoded, and synonymous codon composition: a value of 1 was given to genes that did not belong to the Main cluster. TATA box: a value of 1 was given to genes that had TATA boxes. Common promoter: the maximum value was set as 0.4, because no obvious clusters were found for the analysis of promoter prediction. Then, if a binding site for one of four common transcription factors (nuclear respiratory factor 2 (NRF), GC boxes (GC), Yin and Yang 1 (YY), and activator protein 1 (AP)) was found, a value of 0.1 was subtracted. The columns "Expression profile cluster", "Amino acid encoding cluster", and "Synonymous codon frequency cluster" indicate the clusters to which RP genes were assigned as a result of each analysis. M: Main cluster; S1: Sub-cluster 1; S2: Sub-cluster 2; O: Other. The column "TATA box" indicates the existence of a TATA box, Y: Yes, N: No. For example, FI 3.3 of RPLP0 was calculated as follows; +1.0 (Expression profile), +1.0 (Amino acid encoding cluster), +0 (Synonymous codon frequency), +1.0 (TATA box), +0.4 -0.1 (Predicted Transcription Factors bound).