Figure 3From: Application of DETECTER, an evolutionary genomic tool to analyze genetic variation, to the cystic fibrosis gene familyFrequencies of amino acids lost and gained through missense mutations of the CFTR protein. A, Observed frequencies of native CFTR amino acids lost through phenotypic missense mutations. B, Same as A but normalized for the particular frequencies of amino acids present in the membrane-spanning domains. C, Observed frequencies of non-native amino acids gained through phenotypic missense mutations from the CFTR mutation database.Back to article page