Skip to main content

Table 1 Distribution of CF-causing mutations and the individual amino acid replacement rates of the sites hosting these mutations.

From: Application of DETECTER, an evolutionary genomic tool to analyze genetic variation, to the cystic fibrosis gene family

Normalized replacement rate

Sites

%of sites

Sites with phenotypically significant mutations (O)

Expected sites if randomly distributed (E)

(E-O)2/E

0.0–0.5

44

17

34

18

14.22

0.5–1.0

103

41

45

44

0.02

1.0–1.5

59

23

19

25

1.44

1.5–2.0

25

10

5

11

8.7

2.0–2.5

18

7

3

8

3.1

> 2.5

4

2

2

2

0

 

253

100

108

108

27.48